Neurosurgery Clinic, Department of Head and Neck Surgery, Garibaldi Hospital, Catania, Italy.
Department of Radiation Oncology, REM Radioterapia srl, Viagrande, Italy;
Anticancer Res. 2024 Aug;44(8):3223-3230. doi: 10.21873/anticanres.17140.
BACKGROUND/AIM: The glioblastomas, aggressive brain tumors with a poor prognosis, have drawn interest in their interaction with the glymphatic system-an emerging brain drainage network. This review explores the relationship between glioblastomas and the glymphatic system, aiming to elucidate their impact on disease progression. The aim of the study was to address the alterations in the glymphatic system in the presence of glioblastoma, and their implications for disease pathogenesis and prognosis.
Following PRISMA guidelines, we conducted a systematic literature review, identifying studies on the glymphatic system in glioblastomas. Four high-quality studies were selected based on stringent criteria. Data extraction involved categorizing key findings, and thematic analysis uncovered recurring patterns in glymphatic alterations associated with glioblastomas.
Out of 356 studies, four meeting the high-quality criteria were included. These studies revealed modifications in lymphatic outflow, factors contributing to glymphatic dysfunction, impediments to cerebrospinal fluid drainage, and emerging roles in glioma management. The findings allow a comprehensive understanding of alterations within the glymphatic system in the presence of glioblastoma.
The glymphatic system in glioblastomas exhibits changes, including diminished lymphatic outflow, disruptions and obstacles to fluid drainage, which represent new dimensions in glioma management. These alterations affect drug delivery, immunotherapy, and imaging interpretation. Future research should prioritize elucidating molecular mechanisms, developing therapeutic strategies, optimizing drug delivery, exploring immunotherapy, and translating findings into clinical practice.
背景/目的：胶质母细胞瘤是一种预后较差的侵袭性脑肿瘤，其与脑内淋巴系统（新兴的脑引流网络）的相互作用引起了广泛关注。本综述探讨了胶质母细胞瘤与脑内淋巴系统之间的关系，旨在阐明它们对疾病进展的影响。本研究旨在研究胶质母细胞瘤存在时脑内淋巴系统的改变及其对疾病发病机制和预后的影响。
根据 PRISMA 指南，我们进行了系统的文献综述，确定了关于胶质母细胞瘤中脑内淋巴系统的研究。根据严格的标准，选择了四项高质量的研究。数据提取包括对关键发现进行分类，主题分析揭示了与胶质母细胞瘤相关的脑内淋巴系统改变的重复模式。
从 356 项研究中，有四项符合高质量标准的研究被纳入。这些研究揭示了淋巴流出的改变、导致脑内淋巴功能障碍的因素、对脑脊液引流的阻碍以及在胶质瘤管理中的新作用。这些发现使我们能够全面了解胶质母细胞瘤存在时脑内淋巴系统的改变。
胶质母细胞瘤中的脑内淋巴系统表现出改变，包括淋巴流出减少、流体引流中断和障碍，这为胶质瘤管理提供了新的维度。这些改变影响药物输送、免疫治疗和成像解释。未来的研究应优先阐明分子机制、开发治疗策略、优化药物输送、探索免疫治疗，并将研究结果转化为临床实践。
