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氢氧化钙与精油及Bio-C Temp生物陶瓷根管内药物混合后的细胞相容性及抗生物膜活性

Cytocompatibility and Antibiofilm Activity of Calcium Hydroxide Mixed with Essential Oil and Bio-C Temp Bioceramic Intracanal Medicament.

作者信息

de Magalhães Silveira Cláudia Fernandes, da Silveira Bueno Carlos Eduardo, Schreiber Angélica Zaninelli

机构信息

School of Medical Sciences, State University of Campinas-UNICAMP, Campinas 13083-970, SP, Brazil.

Department of Endodontics, Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Campinas 13045-755, SP, Brazil.

出版信息

Antibiotics (Basel). 2024 Jul 10;13(7):637. doi: 10.3390/antibiotics13070637.

DOI:10.3390/antibiotics13070637
PMID:39061319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274325/
Abstract

Calcium hydroxide represents the most commonly used intracanal dressing between sessions; however, it may not be effective against all types of microorganisms. Several compounds of plant origin have attracted increasing attention from researchers in recent years. The objective of this study was to evaluate the cytocompatibility and antimicrobial activity of calcium hydroxide associated with the essential oil of and the new bioceramic intracanal medicament Bio-C Temp. Five experimental groups were designed: group Ca- essential oil; group CHPG-calcium hydroxide associated with propylene glycol; group CHCa-essential oil of associated with calcium hydroxide; and group U-UltraCal XS; group BCT-Bio-C Temp. The control group was a culture medium. Cytocompatibility was assessed by the methyltetrazolium (MTT) assay after exposure of the Saos-2 human osteoblast-like cell line to dilutions of commercial products/associations for 24 h and 72 h. The antimicrobial activity against mature biofilm was evaluated by the crystal violet assay. All commercial products/associations showed a cell viability similar to or even higher than the control group ( > 0.05) for both periods evaluated. essential oil associated or not with calcium hydroxide showed better antibiofilm capacity. associated or not with calcium hydroxide showed superior cytocompatibility and antimicrobial capacity, representing a promissory intracanal medicament.

摘要

氢氧化钙是根管治疗期间最常用的根管内封药；然而，它可能对所有类型的微生物都无效。近年来，几种植物源化合物引起了研究人员越来越多的关注。本研究的目的是评估氢氧化钙与[植物名称缺失]精油及新型生物陶瓷根管内药物Bio-C Temp联合使用时的细胞相容性和抗菌活性。设计了五个实验组：Ca-精油组；CHPG-氢氧化钙与丙二醇联合组；CHCa-[植物名称缺失]精油与氢氧化钙联合组；U-UltraCal XS组；BCT-Bio-C Temp组。对照组为培养基。将人成骨样细胞系Saos-2暴露于商业产品/联合制剂的稀释液中24小时和72小时后，通过甲基四氮唑（MTT）法评估细胞相容性。通过结晶紫法评估对成熟[细菌名称缺失]生物膜的抗菌活性。在两个评估时间段内，所有商业产品/联合制剂的细胞活力均与对照组相似甚至更高（>0.05）。与氢氧化钙联合或不联合的[植物名称缺失]精油显示出更好的抗生物膜能力。与氢氧化钙联合或不联合的[植物名称缺失]显示出优异的细胞相容性和抗菌能力，是一种有前景的根管内药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/565932aaca3d/antibiotics-13-00637-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/c75e822a9143/antibiotics-13-00637-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/30a82d069102/antibiotics-13-00637-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/cb4ac2233f42/antibiotics-13-00637-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/79bbde81e34a/antibiotics-13-00637-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/5208dafed95f/antibiotics-13-00637-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/565932aaca3d/antibiotics-13-00637-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/c75e822a9143/antibiotics-13-00637-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/30a82d069102/antibiotics-13-00637-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/cb4ac2233f42/antibiotics-13-00637-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/79bbde81e34a/antibiotics-13-00637-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/5208dafed95f/antibiotics-13-00637-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3874/11274325/565932aaca3d/antibiotics-13-00637-g006.jpg

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