Gauch Mirjam, Corsten Sabine, Köb Anna-Lena, Tüscher Oliver, Heinrich Isabel, Geschke Katharina
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Faculty of Healthcare and Nursing, Catholic University of Applied Sciences Mainz, 55122 Mainz, Germany.
Brain Sci. 2024 Jul 11;14(7):692. doi: 10.3390/brainsci14070692.
Persons with primary progressive aphasia (PPA) often experience limitations in their quality of life (QoL). Some studies have shown positive effects of speech and language therapy on QoL in persons with PPA. However, there is still a lack of evidence for disorder-specific approaches for this important therapeutic goal. The biographic-narrative approach (narraktiv) has been shown to significantly improve QoL in persons with post-stroke aphasia. In the planned study, the biographic-narrative approach will be adapted for persons with PPA (Cope PPA), and its efficacy will be investigated. First, a focus group interview with five persons with PPA will be conducted to identify the wishes and needs of participants. Based on the results, the narraktiv manual according to Corsten et al. (2015) will be revised. Second, an efficacy study will be conducted according to the new Cope PPA manual with 24 persons with PPA in a waiting group control design. The primary outcome, QoL, will be assessed using questionnaires (Stroke and Aphasia Quality of Life Scale-39) and semistructured interviews. Depressive symptoms, life satisfaction and cognitive/communicative functioning will also be assessed. If Cope PPA proves efficacy, this study may help to improve the treatment of persons with PPA.
原发性进行性失语（PPA）患者的生活质量（QoL）常常受到限制。一些研究表明，言语和语言治疗对PPA患者的生活质量有积极影响。然而，对于实现这一重要治疗目标的针对特定疾病的方法，仍然缺乏证据。传记叙事法（narraktiv）已被证明能显著提高中风后失语症患者的生活质量。在这项计划中的研究中，传记叙事法将被改编用于PPA患者（Cope PPA），并对其疗效进行研究。首先，将对五名PPA患者进行焦点小组访谈，以确定参与者的愿望和需求。根据结果，将修订Corsten等人（2015年）的narraktiv手册。其次，将根据新的Cope PPA手册，采用等待组对照设计，对24名PPA患者进行疗效研究。主要结局指标，即生活质量，将通过问卷调查（《中风与失语症生活质量量表-39》）和半结构化访谈进行评估。抑郁症状、生活满意度以及认知/沟通功能也将进行评估。如果Cope PPA被证明有效，这项研究可能有助于改善PPA患者的治疗。
