正常眼压性青光眼和原发性开角型青光眼患者黄斑区视网膜和脉络膜的光学相干断层扫描血管造影
OCT Angiography of the Retina and the Choroid in the Macula in Patients with Normal Tension Glaucoma and Primary Open Angle Glaucoma.
作者信息
Dastiridou Anna, Samouilidou Maria, Anastasopoulos Eleftherios, Koronis Spyridon, Riga Paraskevi, Katsanos Andreas, Ziakas Nikolaos, Androudi Sofia
机构信息
Ophthalmology Clinic, University Hospital of Larissa, University of Thessaly, 41110 Larissa, Greece.
2nd Ophthalmology Clinic, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece.
出版信息
Diagnostics (Basel). 2024 Jul 11;14(14):1485. doi: 10.3390/diagnostics14141485.
The aim of this study was to compare vessel density (VD) in the retina and choroid in eyes with primary open angle glaucoma (POAG), normal tension glaucoma (NTG) and controls. Patients with POAG, NTG and controls underwent OCT scanning of the macula and the disc followed by 6 × 6 mm macula OCT angiography (OCTA) imaging. Global and hemifield VD were recorded for the superficial (SVP) and deep (DVP) vascular plexus and the choriocapillaris (CC). The OCT thickness of the nerve fiber layer (NFL) and ganglion cell layer (GCC) was also measured. Data from 65 POAG, 33 NTG and 40 control eyes matched for age were analyzed. Mean SVP VD was lower in NTG and POAG eyes compared to controls (38.8 ± 5.3, 40.7 ± 6.8 and 48.5 ± 4.0%, < 0.001). Mean DVP VD was lower in NTG and POAG eyes compared to controls (43.1 ± 6.1, 44.5 ± 7.6 and 48.6 ± 5.8%, = 0.002). There was no difference in SVP VD or DVP VD between the glaucoma groups ( > 0.050). No difference was noted in CC VD between the groups (68.3 ± 2.3, 67.6 ± 3.7 and 68.5 ± 2.6%, = 0.287). Lower SVP and DVP VD was seen in eyes with glaucoma compared to normal eyes. NTG and POAG eyes had similar VD loss. Eyes with glaucoma manifested similar CC VD compared to controls.
本研究的目的是比较原发性开角型青光眼（POAG）、正常眼压性青光眼（NTG）患者及对照者眼睛视网膜和脉络膜的血管密度（VD）。POAG、NTG患者及对照者接受黄斑和视盘的光学相干断层扫描（OCT），随后进行6×6mm黄斑OCT血管造影（OCTA）成像。记录浅层（SVP）和深层（DVP）血管丛以及脉络膜毛细血管（CC）的整体和半视野VD。还测量了神经纤维层（NFL）和神经节细胞层（GCC）的OCT厚度。分析了65只POAG、33只NTG和40只年龄匹配的对照眼的数据。与对照者相比，NTG和POAG患者眼睛的平均SVP VD较低（分别为38.8±5.3%、40.7±6.8%和48.5±4.0%，<0.001）。与对照者相比，NTG和POAG患者眼睛的平均DVP VD较低（分别为43.1±6.1%、44.5±7.6%和48.6±5.8%，=0.002）。青光眼组之间的SVP VD或DVP VD没有差异（>0.050）。各组之间的CC VD没有差异（分别为68.3±2.3%、67.6±3.7%和68.5±2.6%，=0.287）。与正常眼睛相比，青光眼患者眼睛的SVP和DVP VD较低。NTG和POAG患者眼睛的VD损失相似。与对照者相比，青光眼患者眼睛的CC VD相似。
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