Lin Yun-Hsuan, Huang Shih-Ming, Yeung Ling, Ku Wan-Chen, Chen Henry Shen-Lih, Lai Chi-Chun, Chuang Lan-Hsin
Department of Electro-Optical Engineering, National Taipei University of Technology, Taipei, Taiwan.
Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Transl Vis Sci Technol. 2020 Dec 17;9(13):26. doi: 10.1167/tvst.9.13.26. eCollection 2020 Dec.
To investigate the retinal vessel density (VD) in healthy and normal-tension glaucoma (NTG) eyes through optical coherence tomography angiography (OCTA) and to determine the correlation between VD and the retinal nerve fiber layer (RNFL) thickness and functional visual field (VF) defects for different locations.
A total of 74 NTG eyes and 24 healthy eyes were included. OCTA VD at 4.5 × 4.5 mm peripapillary region and 3.0 × 3.0 mm macula area, RNFL thickness, and VF pattern deviation results were individually analyzed on the basis of the Garway-Heath sectorization. Correlations between VD and VF/RNFL and VF were compared.
In the NTG group, peripapillary VD, superficial macula VD, RNFL thickness, and ganglion cell complex thickness were significantly lower. In the whole peripapillary area and inferotemporal sector, anatomic correlations between VD and VF pattern deviation values were significantly higher than those between the RNFL thickness and VF values. In the subgroup analysis, VD was anatomically correlated with VF in early-, moderate-, and severe-stage NTG eyes, whereas the RNFL thickness was correlated with VF in moderate- and severe-stage NTG eyes.
We observed VD reduction in the peripapillary retina and superficial macula area in NTG eyes. The microvascular dropout of VD in the peripapillary retina, especially in the inferotemporal sector, provided a more accurate anatomic correlation with functional VF defects than that of the RNFL thickness, especially in early-stage NTG eyes.
In patients who cannot comply VF exam, VD is a good tool for disease detection.
通过光学相干断层扫描血管造影（OCTA）研究健康眼和正常眼压性青光眼（NTG）眼中的视网膜血管密度（VD），并确定不同位置的VD与视网膜神经纤维层（RNFL）厚度及功能性视野（VF）缺损之间的相关性。
共纳入74只NTG眼和24只健康眼。基于Garway-Heath扇形分区，分别分析视乳头周围4.5×4.5mm区域和黄斑区3.0×3.0mm的OCTA血管密度、RNFL厚度及VF模式偏差结果。比较VD与VF/RNFL以及VF之间的相关性。
在NTG组中，视乳头周围VD、黄斑浅层VD、RNFL厚度和神经节细胞复合体厚度显著降低。在整个视乳头周围区域和颞下扇形区，VD与VF模式偏差值之间的解剖学相关性显著高于RNFL厚度与VF值之间的相关性。在亚组分析中，早期、中期和重度NTG眼中VD与VF存在解剖学相关性，而中期和重度NTG眼中RNFL厚度与VF相关。
我们观察到NTG眼中视乳头周围视网膜和黄斑浅层区域的VD降低。视乳头周围视网膜中VD的微血管缺失，尤其是在颞下扇形区，与功能性VF缺损的解剖学相关性比RNFL厚度更准确，尤其是在早期NTG眼中。
对于无法配合VF检查的患者，VD是疾病检测的良好工具。
