Zhang Tianyu, Liao Jinpeng, Zhang Yilong, Huang Zhihong, Li Chunhui
Centre for Medical Engineering and Technology (CMET), School of Science and Engineering, University of Dundee, Dundee DD1 4HN, UK.
Diagnostics (Basel). 2024 Jul 12;14(14):1509. doi: 10.3390/diagnostics14141509.
The current methods to generate projections for structural and angiography imaging of Fourier-Domain optical coherence tomography (FD-OCT) are significantly slow for prediagnosis improvement, prognosis, real-time surgery guidance, treatments, and lesion boundary definition. This study introduced a robust ultrafast projection pipeline (RUPP) and aimed to develop and evaluate the efficacy of RUPP. RUPP processes raw interference signals to generate structural projections without the need for Fourier Transform. Various angiography reconstruction algorithms were utilized for efficient projections. Traditional methods were compared to RUPP using PSNR, SSIM, and processing time as evaluation metrics. The study used 22 datasets (hand skin: 9; labial mucosa: 13) from 8 volunteers, acquired with a swept-source optical coherence tomography system. RUPP significantly outperformed traditional methods in processing time, requiring only 0.040 s for structural projections, which is 27 times faster than traditional summation projections. For angiography projections, the best RUPP variation took 0.15 s, making it 7518 times faster than the windowed eigen decomposition method. However, PSNR decreased by 41-45% and SSIM saw reductions of 25-74%. RUPP demonstrated remarkable speed improvements over traditional methods, indicating its potential for real-time structural and angiography projections in FD-OCT, thereby enhancing clinical prediagnosis, prognosis, surgery guidance, and treatment efficacy.
目前用于傅里叶域光学相干断层扫描（FD - OCT）结构和血管造影成像的投影生成方法，在改善预诊断、预后、实时手术指导、治疗以及病变边界定义方面速度明显过慢。本研究引入了一种强大的超快速投影流程（RUPP），旨在开发并评估RUPP的功效。RUPP处理原始干涉信号以生成结构投影，无需进行傅里叶变换。利用各种血管造影重建算法来实现高效投影。使用峰值信噪比（PSNR）、结构相似性（SSIM）和处理时间作为评估指标，将传统方法与RUPP进行比较。该研究使用了来自8名志愿者的22个数据集（手部皮肤：9个；唇黏膜：13个），这些数据集是通过扫频源光学相干断层扫描系统采集的。RUPP在处理时间上显著优于传统方法，生成结构投影仅需0.040秒，比传统求和投影快27倍。对于血管造影投影，最佳的RUPP变体耗时0.15秒，比窗口特征分解方法快7518倍。然而，PSNR下降了41 - 45%，SSIM降低了25 - 74%。RUPP相较于传统方法在速度上有显著提升，表明其在FD - OCT实时结构和血管造影投影方面具有潜力，从而可提高临床预诊断、预后、手术指导和治疗效果。
