Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, 1090 Vienna, Austria.
Photochem Photobiol Sci. 2019 May 15;18(5):945-962. doi: 10.1039/c8pp00471d.
Optical coherence tomography angiography (OCTA) is a relatively novel functional extension of the widely accepted ophthalmic imaging tool named optical coherence tomography (OCT). Since OCTA's debut in ophthalmology, researchers have also been trying to expand its translational application in dermatology. The ability of OCTA to resolve microvasculature has shown promising results in imaging skin diseases. Meanwhile, photoacoustic imaging (PAI), which uses laser pulse induced ultrasound waves as the signal, has been studied to differentiate human skin layers and to help in skin disease diagnosis. This perspective article gives a short review of OCTA and PAI in the field of photodermatology. After an introduction to the principles of OCTA and PAI, we describe the most updated results of skin disease imaging using these two optical imaging modalities. We also place emphasis on dual modality imaging combining OCTA and photoacoustic tomography (PAT) for dermatological applications. In the end, the challenges and prospects of these two imaging modalities in dermatology are discussed.
光学相干断层扫描血管造影术 (OCTA) 是一种广泛应用的眼科成像工具——光学相干断层扫描 (OCT) 的相对较新的功能扩展。自 OCTA 在眼科领域问世以来，研究人员也一直在尝试将其在皮肤科的转化应用扩展。OCTA 分辨微血管的能力在成像皮肤病方面显示出了有前景的结果。同时，光声成像 (PAI) 利用激光脉冲产生的超声波作为信号，已被研究用于区分人体皮肤层并帮助皮肤疾病诊断。本文对视光皮肤病学领域的 OCTA 和 PAI 进行了简要综述。在介绍了 OCTA 和 PAI 的原理之后，我们描述了使用这两种光学成像方式对皮肤病进行成像的最新结果。我们还重点介绍了 OCTA 和光声断层扫描 (PAT) 联合用于皮肤科应用的双模式成像。最后，讨论了这两种成像方式在皮肤科应用中的挑战和前景。
