Masdipa Andi, Kaidzu Sachiko, Tanito Masaki
Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.
Bioengineering (Basel). 2024 Jun 29;11(7):669. doi: 10.3390/bioengineering11070669.
To evaluate the effectiveness of the PRESERFLO MicroShunt (PFM) in reducing intraocular pressure (IOP) ex vivo in porcine eyes using an infusion pump system and to simulate various IOP conditions, In this study, porcine eyes received increasing flows between 2 and 20 μL/min. IOP measurements were taken under conditions with and without the PFM [PFM (+) and PFM (-), respectively]. In the PFM (-) group, IOP increased from 7.4 mmHg to 46.3 mmHg as the flow rate increased from 2 μL/min to 20 μL/min. The rate of IOP reduction (%ΔIOP) rose with increasing flow rates, although the absolute IOP values achieved with the PFM insertion also increased. The correlation between IOPs in the PFM (-) conditions and the %ΔIOP was modeled as %ΔIOP = 22.4 Ln [PFM(-) IOP] - 41.7. According to this equation, IOP reduction by PFM insertion is 0% at IOPs of 6.4 mmHg or lower. IOP reductions of 10%, 20%, 30%, and 40% were observed when the pre-insertion IOPs were 10.1, 15.7, 24.6, and 38.4 mmHg, respectively. Achievable post-insertion IOP levels of ≤21 mmHg, ≤18 mmHg, ≤15 mmHg, and ≤12 mmHg corresponded to the initial IOPs of 33 mmHg, 26 mmHg, 20 mmHg, and 14.8 mmHg, respectively. In conclusion, the PFM effectively reduced IOP within a specific range of IOP values in an ex vivo experimental system. In clinical situations, the PFM is unlikely to be effective at low IOP levels. At higher levels, the PFM reduces IOP, but it may be insufficient to achieve the target IOP.
为了评估PRESERFLO微型分流器（PFM）在使用输液泵系统降低猪眼离体眼压（IOP）方面的有效性，并模拟各种IOP条件，在本研究中，猪眼接受了2至20μL/分钟之间逐渐增加的流量。在有和没有PFM的条件下（分别为PFM（+）和PFM（-））进行IOP测量。在PFM（-）组中，随着流速从2μL/分钟增加到20μL/分钟，IOP从7.4 mmHg增加到46.3 mmHg。尽管插入PFM后获得的绝对IOP值也增加，但IOP降低率（%ΔIOP）随着流速增加而上升。PFM（-）条件下的IOP与%ΔIOP之间的相关性被建模为%ΔIOP = 22.4 Ln [PFM（-）IOP] - 41.7。根据该方程，在6.4 mmHg或更低的IOP时，插入PFM导致的IOP降低为0%。当插入前的IOP分别为10.1、15.7、24.6和38.4 mmHg时，观察到IOP降低了10%、20%、30%和40%。插入后可达到的IOP水平≤21 mmHg、≤18 mmHg、≤15 mmHg和≤12 mmHg分别对应于初始IOP为33 mmHg、26 mmHg、20 mmHg和14.8 mmHg。总之，在离体实验系统中，PFM在特定IOP值范围内有效降低IOP。在临床情况下，PFM在低IOP水平时不太可能有效。在较高水平时，PFM可降低IOP，但可能不足以达到目标IOP。
