Zhao Yiming, Li Chunyan, Wu Kaijuan, Chen Hao, Wang Qingqun, Xiao Ying, Yao Siqi, Hong Ao, Zhang Man, Lei Shibo, Yang Wenyu, Zhong Shukun, Umar Abdulrahim, Huang Jing, Yu Zheng
Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha 410013, China.
Human Microbiome and Health Group, Department of Parasitology, School of Basic Medical Science, Central South University, Changsha 410013, China.
Biomedicines. 2024 Jun 21;12(7):1378. doi: 10.3390/biomedicines12071378.
Although travelers are frequently accompanied by abdominal discomfort and even diarrhea, not every trip can cause this issue. Many studies have reported that intestinal microbes play an important role in it. However, little is known about the reason for the dynamics of these intestinal microbes. Here, we delved into the effects of short-term travel on the gut microbiota of 12 healthy individuals. A total of 72 fecal samples collected before and after one-week travel, alongside non-traveling controls, underwent amplicon sequencing and a series of bioinformatic analyses. We found that travel significantly increased intra-individual gut microbiota fluctuations without diarrhea symptoms. In addition, the initial composition of the gut microbiota before travel emerged as a crucial factor in understanding these fluctuations. Travelers with stable microbiota exhibited an enrichment of specific probiotic bacteria (, , , , ) before travel. Another batch of data validated their predictive role in distinguishing travelers with and without the gut microbial disorder. This work provided valuable insights into understanding the relationship between gut microbiota and travel. It offered a microbiota-centric perspective and a potential avenue for interventions to preserve gut health during travel.
尽管旅行者经常伴有腹部不适甚至腹泻，但并非每次旅行都会引发这个问题。许多研究报告称肠道微生物在其中起重要作用。然而，对于这些肠道微生物动态变化的原因却知之甚少。在此，我们深入研究了短期旅行对12名健康个体肠道微生物群的影响。总共收集了一周旅行前后以及非旅行对照组的72份粪便样本，进行了扩增子测序和一系列生物信息学分析。我们发现旅行显著增加了个体内肠道微生物群的波动，且无腹泻症状。此外，旅行前肠道微生物群的初始组成成为理解这些波动的关键因素。微生物群稳定的旅行者在旅行前表现出特定益生菌（、、、、）的富集。另一批数据验证了它们在区分有无肠道微生物紊乱旅行者方面的预测作用。这项工作为理解肠道微生物群与旅行之间的关系提供了有价值的见解。它提供了一个以微生物群为中心的视角以及在旅行期间维护肠道健康的潜在干预途径。
