细胞外囊泡与免疫系统功能：探索结直肠癌免疫治疗的新方法

Extracellular Vesicles and Immune System Function: Exploring Novel Approaches to Colorectal Cancer Immunotherapy.

作者信息

Biondi Antonio, Vacante Marco, Catania Roberta, Sangiorgio Giuseppe

机构信息

Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.

Unit of Internal Medicine Critical Area-ARNAS Garibaldi, Piazza Santa Maria di Gesù, 5, 95124 Catania, Italy.

出版信息

Biomedicines. 2024 Jul 3;12(7):1473. doi: 10.3390/biomedicines12071473.

DOI:10.3390/biomedicines12071473

PMID:39062046

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11275211/

Abstract

This review explores the emerging role of extracellular vesicles (EVs) in modulating immune system function and their application in novel cancer immunotherapy strategies, with a focus on colorectal cancer (CRC). EVs, as carriers of bioactive molecules, have shown potential in enhancing immune responses and overcoming the limitations of traditional therapies. We discuss the biogenesis, types, and functional roles of immune cell-derived EVs, their interactions with cancer cells, and their implications in antitumor immunity. Challenges such as tumor heterogeneity and immune evasion are addressed, alongside the promising therapeutic prospects of EV-based strategies. This comprehensive analysis underscores the transformative potential of EVs in cancer treatment paradigms.

摘要

本综述探讨了细胞外囊泡（EVs）在调节免疫系统功能中的新兴作用及其在新型癌症免疫治疗策略中的应用，重点关注结直肠癌（CRC）。作为生物活性分子的载体，EVs在增强免疫反应和克服传统疗法的局限性方面显示出潜力。我们讨论了免疫细胞衍生的EVs的生物发生、类型和功能作用，它们与癌细胞的相互作用，以及它们在抗肿瘤免疫中的意义。同时探讨了肿瘤异质性和免疫逃逸等挑战，以及基于EVs的策略所具有的广阔治疗前景。这一全面分析强调了EVs在癌症治疗模式中的变革潜力。