Basic Medical College, Department of Pathology, Guangdong Medical University, Dongguan, Guangdong, China.
Professor in Basic Medical College, Department of Pathology, Guangdong Medical University, Dongguan, Guangdong, China.
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231198348. doi: 10.1177/15330338231198348.
In recent years, genitourinary system tumors are common in people of all ages, seriously affecting the quality of life of patients, the pathogenesis and treatment of these diseases are constantly being updated and improved. Exosomes, with a lipid bilayer that enable delivery of their contents into body fluids or other cells. Exosomes can regulate the tumor microenvironment, and play an important role in tumor development. In turn, cellular and non-cellular components of tumor microenvironment also affect the occurrence, progression, invasion and metastasis of tumor. Non-coding RNAs have been shown to be able to be ingested and released by exosomes, and are seen as a potential tool in cancer diagnosis and treatment. Here, we summarize the effect of non-coding RNAs of exosome contents on the tumor microenvironment of genitourinary system tumor, expound the significance of non-coding RNAs of exosome in the occurrence, development, diagnosis and treatment of cancers.
近年来，泌尿系统肿瘤在各年龄段人群中均较为常见，严重影响患者的生活质量，其发病机制和治疗方法也在不断更新和完善。外泌体具有双层脂膜，可将其内容物递送至体液或其他细胞中。外泌体可以调节肿瘤微环境，在肿瘤发生发展中发挥重要作用。反过来，肿瘤微环境中的细胞和非细胞成分也会影响肿瘤的发生、进展、侵袭和转移。现已证实，非编码 RNA 能够被外泌体摄取和释放，并被视为癌症诊断和治疗的潜在工具。在这里，我们总结了外泌体内容物中非编码 RNA 对泌尿系统肿瘤肿瘤微环境的影响，阐述了外泌体中非编码 RNA 在癌症发生、发展、诊断和治疗中的意义。
