Díaz Del Arco Cristina, Estrada Muñoz Lourdes, Cerón Nieto María de Los Ángeles, Molina Roldán Elena, Fernández Aceñero María Jesús, García Gómez de Las Heras Soledad
Department of Legal Medicine, Psychiatry and Pathology, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Department of Pathology, Hospital Clínico San Carlos, Health Research Institute of the Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
Biomedicines. 2024 Jul 7;12(7):1508. doi: 10.3390/biomedicines12071508.
Galectin-1 (Gal-1), a member of the human lectin family, has garnered attention for its association with aggressive behavior in human tumors, prompting research into the development of targeted drugs. This study aims to assess the staining pattern and prognostic significance of Gal-1 immunohistochemical expression in a homogeneous cohort of Western patients with gastric cancer (GC). A total of 149 cases were included and tissue microarrays were constructed. Stromal Gal-1 expression was observed to some extent in most tumors, displaying a cytoplasmic pattern. Cases with stromal Gal-1 overexpression showed significantly more necrosis, lymphovascular invasion, advanced pTNM stages, recurrences, and cancer-related deaths. Epithelial Gal-1 expression was present in 63.8% of the cases, primarily exhibiting a cytoplasmic pattern, and its overexpression was significantly associated with lymphovascular invasion, peritumoral lymphocytic infiltration, and tumor-related death. Kaplan/Meier curves for cancer-specific survival (CSS) revealed a significantly worse prognosis for patients with tumors exhibiting stromal or epithelial Gal-1 overexpression. Furthermore, stromal Gal-1 expression stratified stage III patients into distinct prognostic subgroups. In a multivariable analysis, increased stromal Gal-1 expression emerged as an independent prognostic factor for CSS. These findings underscore the prognostic relevance of Gal-1 and suggest its potential as a target for drug development in Western patients with GC.
半乳糖凝集素-1（Gal-1）是人类凝集素家族的一员，因其与人类肿瘤侵袭性行为的关联而受到关注，这促使人们对靶向药物的开发进行研究。本研究旨在评估Gal-1免疫组化表达在一组同质的西方胃癌（GC）患者中的染色模式和预后意义。共纳入149例病例并构建组织微阵列。在大多数肿瘤中均观察到一定程度的基质Gal-1表达，呈细胞质模式。基质Gal-1过表达的病例显示出明显更多的坏死、淋巴管侵犯、pTNM分期较晚、复发和癌症相关死亡。63.8%的病例存在上皮Gal-1表达，主要呈细胞质模式，其过表达与淋巴管侵犯、肿瘤周围淋巴细胞浸润和肿瘤相关死亡显著相关。癌症特异性生存（CSS）的Kaplan/Meier曲线显示，基质或上皮Gal-1过表达的肿瘤患者预后明显更差。此外，基质Gal-1表达将III期患者分为不同的预后亚组。在多变量分析中，基质Gal-1表达增加是CSS的独立预后因素。这些发现强调了Gal-1的预后相关性，并表明其在西方GC患者中作为药物开发靶点的潜力。
