Hani Umme, Osmani Riyaz Ali M, Yasmin Sabina, Gowda B H Jaswanth, Ather Hissana, Ansari Mohammad Yousuf, Siddiqua Ayesha, Ghazwani Mohammed, Fatease Adel Al, Alamri Ali H, Rahamathulla Mohamed, Begum M Yasmin, Wahab Shadma
Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSS AHER), Mysuru 570015, Karnataka, India.
Pharmaceutics. 2022 Jul 29;14(8):1576. doi: 10.3390/pharmaceutics14081576.
Cancer has long been regarded as one of the world's most fatal diseases, claiming the lives of countless individuals each year. Stomach cancer is a prevalent cancer that has recently reached a high number of fatalities. It continues to be one of the most fatal cancer forms, requiring immediate attention due to its low overall survival rate. Early detection and appropriate therapy are, perhaps, of the most difficult challenges in the fight against stomach cancer. We focused on positive tactics for stomach cancer therapy in this paper, and we went over the most current advancements and progressions of nanotechnology-based systems in modern drug delivery and therapies in great detail. Recent therapeutic tactics used in nanotechnology-based delivery of drugs aim to improve cellular absorption, pharmacokinetics, and anticancer drug efficacy, allowing for more precise targeting of specific agents for effective stomach cancer treatment. The current review also provides information on ongoing research aimed at improving the curative effectiveness of existing anti-stomach cancer medicines. All these crucial matters discussed under one overarching title will be extremely useful to readers who are working on developing multi-functional nano-constructs for improved diagnosis and treatment of stomach cancer.
癌症长期以来一直被视为世界上最致命的疾病之一，每年夺去无数人的生命。胃癌是一种常见的癌症，最近导致了大量死亡。它仍然是最致命的癌症形式之一，由于其总体生存率较低，需要立即引起关注。早期检测和适当治疗可能是对抗胃癌最艰巨的挑战之一。在本文中，我们专注于胃癌治疗的积极策略，并详细回顾了基于纳米技术的系统在现代药物递送和治疗方面的最新进展。基于纳米技术的药物递送中使用的最新治疗策略旨在提高细胞吸收、药代动力学和抗癌药物疗效，从而更精确地靶向特定药物以有效治疗胃癌。本综述还提供了有关旨在提高现有抗胃癌药物疗效的正在进行的研究的信息。在一个总体标题下讨论的所有这些关键问题对于致力于开发用于改善胃癌诊断和治疗的多功能纳米结构的读者将极为有用。
