Syed Hashim Syed Alhafiz, Naina Mohamed Isa, Mohamed Norazlina
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.
Biomedicines. 2024 Jul 8;12(7):1515. doi: 10.3390/biomedicines12071515.
Alcohol's detrimental effects on bone health are well established, yet some literature suggests moderate consumption may offer benefits. With alcohol use on the rise, we investigate the impact of acute and chronic alcohol administration, along with withdrawal, on male Wistar rat femurs. We observed a transient cortical thickness increase with acute alcohol (AA) compared to chronic exposure (CA) but no significant changes in trabecular parameters or mechanical properties. High osteocalcin and osteopontin expression levels were noted in AA, alongside elevated RANKL expression. Conversely, CA showed low TRAP levels. FGF23 expression significantly increased during alcohol withdrawal (AW), while GPX decreased after chronic exposure but rose during withdrawal. Although mechanical strength changes were insignificant, biochemical shifts suggest alcohol exposure promotes bone resorption, reduces antioxidant protection, and potentially hampers active vitamin D and phosphate reabsorption via FGF23 upregulation.
酒精对骨骼健康的有害影响已得到充分证实，但一些文献表明适度饮酒可能有益。随着酒精消费量的上升，我们研究了急性和慢性酒精给药以及戒酒对雄性Wistar大鼠股骨的影响。与慢性酒精暴露（CA）相比，我们观察到急性酒精（AA）使皮质厚度短暂增加，但小梁参数或力学性能无显著变化。在AA组中观察到骨钙素和骨桥蛋白表达水平较高，同时RANKL表达升高。相反，CA组显示TRAP水平较低。在戒酒（AW）期间，FGF23表达显著增加，而GPX在慢性暴露后降低，但在戒酒期间升高。尽管力学强度变化不显著，但生化变化表明酒精暴露会促进骨吸收，降低抗氧化保护，并可能通过上调FGF23阻碍活性维生素D和磷酸盐的重吸收。
