基于纳米纤维的冈上肌腱再生工程基质。
Nanofiber-based matrices for rotator cuff regenerative engineering.
机构信息
Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA; Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA; Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA; Department of Chemical & Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA.
出版信息
Acta Biomater. 2019 Aug;94:64-81. doi: 10.1016/j.actbio.2019.05.041. Epub 2019 May 23.
The rotator cuff consists of a cuff of soft tissue responsible for rotating the shoulder. Rotator cuff tendon tears are responsible for a significant source of disability and pain in the adult population. Most rotator cuff tendon tears occur at the bone-tendon interface. Tear size, patient age, fatty infiltration of muscle, have a major influence on the rate of retear after surgical repair. The high incidence of retears (up to 94% in some studies) after surgery makes rotator cuff injuries a critical musculoskeletal problem to address. The limitations of current treatments motivate regenerative engineering approaches for rotator cuff regeneration. Various fiber-based matrices are currently being investigated due to their structural similarity with native tendons and their ability to promote regeneration. This review will discuss the current approaches for rotator cuff regeneration, recent advances in fabrication and enhancement of nanofiber-based matrices and the development and use of complex nano/microstructures for rotator cuff regeneration. STATEMENT OF SIGNIFICANCE: Regeneration paradigms for musculoskeletal tissues involving the rotator cuff of the shoulder have received great interest. Novel technologies based on nanomaterials have emerged as possible robust solutions for rotator cuff injury and treatment due to structure/property relationships. The aim of the review submitted is to comprehensively describe and evaluate the development and use of nano-based material technologies for applications to rotator cuff tendon healing and regeneration.
肩袖由负责旋转肩部的软组织袖组成。肩袖肌腱撕裂是成年人残疾和疼痛的重要原因。大多数肩袖肌腱撕裂发生在骨-肌腱交界处。撕裂的大小、患者年龄、肌肉脂肪浸润对手术修复后的再撕裂率有很大影响。手术后再撕裂的发生率很高（在一些研究中高达 94%），这使得肩袖损伤成为一个需要解决的关键肌肉骨骼问题。目前治疗方法的局限性促使人们采用再生工程方法来进行肩袖再生。由于与天然肌腱的结构相似性及其促进再生的能力，各种纤维基基质目前正在被研究。本文综述将讨论肩袖再生的当前方法、纳米纤维基基质的制造和增强方面的最新进展，以及用于肩袖再生的复杂纳米/微结构的开发和使用。
意义声明
涉及肩部肩袖的肌肉骨骼组织的再生范式引起了广泛关注。由于结构/性能关系，基于纳米材料的新技术已成为肩袖损伤和治疗的可行的强力解决方案。提交的综述旨在全面描述和评估纳米材料技术在肩袖肌腱愈合和再生应用中的发展和使用。
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