• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

探索异黄酮类化合物的抗血管生成和抗炎潜力：使用生物素探针进行的靶标鉴定。

Exploring the Antiangiogenic and Anti-Inflammatory Potential of Homoisoflavonoids: Target Identification Using Biotin Probes.

机构信息

College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.

出版信息

Biomolecules. 2024 Jun 30;14(7):785. doi: 10.3390/biom14070785.

DOI:10.3390/biom14070785
PMID:39062499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274659/
Abstract

Chemical proteomics using biotin probes of natural products have significantly advanced our understanding of molecular targets and therapeutic potential. This review highlights recent progress in the application of biotin probes of homoisoflavonoids for identifying binding proteins and elucidating mechanisms of action. Notably, homoisoflavonoids exhibit antiangiogenic, anti-inflammatory, and antidiabetic effects. A combination of biotin probes, pull-down assays, mass spectrometry, and molecular modeling has revealed how natural products and their derivatives interact with several proteins such as ferrochelatase (FECH), soluble epoxide hydrolase (sEH), inosine monophosphate dehydrogenase 2 (IMPDH2), phosphodiesterase 4 (PDE4), and deoxyhypusine hydroxylase (DOHH). These target identification approaches pave the way for new therapeutic avenues, especially in the fields of oncology and ophthalmology. Future research aimed at expanding the repertoire of target identification using biotin probes of homoisoflavonoids promises to further elucidate the complex mechanisms and develop new drug candidates.

摘要

利用天然产物生物素探针的化学蛋白质组学研究显著促进了我们对分子靶标和治疗潜力的理解。本综述重点介绍了同型异黄酮生物素探针在鉴定结合蛋白和阐明作用机制方面的最新进展。值得注意的是，同型异黄酮具有抗血管生成、抗炎和抗糖尿病作用。生物素探针、下拉测定、质谱和分子建模的组合揭示了天然产物及其衍生物如何与几种蛋白质相互作用，如亚铁螯合酶 (FECH)、可溶性环氧化物水解酶 (sEH)、肌苷单磷酸脱氢酶 2 (IMPDH2)、磷酸二酯酶 4 (PDE4) 和脱氧次黄嘌呤羟化酶 (DOHH)。这些靶标鉴定方法为新的治疗途径铺平了道路，特别是在肿瘤学和眼科学领域。未来旨在扩大同型异黄酮生物素探针靶标鉴定谱的研究有望进一步阐明复杂机制并开发新的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/8cb1cd2ddfd4/biomolecules-14-00785-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/e27e5ae765e0/biomolecules-14-00785-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/b2e1404e1d58/biomolecules-14-00785-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/da05e25b49a6/biomolecules-14-00785-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/39a5228890e8/biomolecules-14-00785-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/d3029cc1cd8c/biomolecules-14-00785-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/935a0cca296a/biomolecules-14-00785-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/e45a6ecaf5bf/biomolecules-14-00785-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/f5a4f0499203/biomolecules-14-00785-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/b7ed27086b73/biomolecules-14-00785-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/91c8bc54595c/biomolecules-14-00785-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/8cb1cd2ddfd4/biomolecules-14-00785-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/e27e5ae765e0/biomolecules-14-00785-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/b2e1404e1d58/biomolecules-14-00785-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/da05e25b49a6/biomolecules-14-00785-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/39a5228890e8/biomolecules-14-00785-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/d3029cc1cd8c/biomolecules-14-00785-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/935a0cca296a/biomolecules-14-00785-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/e45a6ecaf5bf/biomolecules-14-00785-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/f5a4f0499203/biomolecules-14-00785-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/b7ed27086b73/biomolecules-14-00785-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/91c8bc54595c/biomolecules-14-00785-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a01c/11274659/8cb1cd2ddfd4/biomolecules-14-00785-g011.jpg

相似文献

1
Exploring the Antiangiogenic and Anti-Inflammatory Potential of Homoisoflavonoids: Target Identification Using Biotin Probes.探索异黄酮类化合物的抗血管生成和抗炎潜力：使用生物素探针进行的靶标鉴定。
Biomolecules. 2024 Jun 30;14(7):785. doi: 10.3390/biom14070785.
2
Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.抗血管生成高异黄酮类光亲和探针的设计、合成及生物学评价
Bioorg Med Chem Lett. 2016 Sep 1;26(17):4277-81. doi: 10.1016/j.bmcl.2016.07.043. Epub 2016 Jul 21.
3
Naturally occurring homoisoflavonoids and their pharmacological activities.天然存在的高异黄酮及其药理活性。
Planta Med. 2014 Aug;80(13):1053-66. doi: 10.1055/s-0034-1383026. Epub 2014 Aug 25.
4
Homoisoflavonoids as potential antiangiogenic agents for retinal neovascularization.同型异黄酮类化合物作为抗视网膜新生血管形成的潜在血管生成抑制剂。
Biomed Pharmacother. 2017 Nov;95:818-827. doi: 10.1016/j.biopha.2017.09.004. Epub 2017 Sep 10.
5
[Recent advances in the study of natural homoisoflavonoids].[天然高异黄酮类化合物的研究新进展]
Yao Xue Xue Bao. 2007 Feb;42(2):118-26.
6
Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization.用于视网膜新生血管形成的新型高异黄酮类化合物的合成与生物学评价
J Med Chem. 2015 Jun 25;58(12):5015-5027. doi: 10.1021/acs.jmedchem.5b00449. Epub 2015 Jun 16.
7
Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity.麦冬根中的高异黄酮衍生物及其体外抗炎活性。
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2412-6. doi: 10.1016/j.bmcl.2010.03.043. Epub 2010 Mar 11.
8
Antiangiogenic Activity and Cytotoxicity of Triterpenoids and Homoisoflavonoids from Massonia pustulata and Massonia bifolia.来自脓疱锦枣儿和双叶锦枣儿的三萜类化合物和高异黄酮类化合物的抗血管生成活性及细胞毒性
Planta Med. 2018 Jul;84(9-10):638-644. doi: 10.1055/a-0577-5322. Epub 2018 Feb 28.
9
Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus.来源于麦冬块根的具有抗炎作用的异黄酮。
Fitoterapia. 2012 Sep;83(6):1042-5. doi: 10.1016/j.fitote.2012.05.011. Epub 2012 May 22.
10
Natural phosphodiesterase-4 (PDE4) inhibitors from Crotalaria ferruginea.从槐蓝中提取的天然磷酸二酯酶-4（PDE4）抑制剂。
Fitoterapia. 2014 Apr;94:177-82. doi: 10.1016/j.fitote.2014.02.010. Epub 2014 Mar 2.

引用本文的文献

1
Target identification of natural products in cancer with chemical proteomics and artificial intelligence approaches.利用化学蛋白质组学和人工智能方法鉴定癌症中天然产物的靶点
Cancer Biol Med. 2025 Jul 9;22(6):549-97. doi: 10.20892/j.issn.2095-3941.2025.0145.

本文引用的文献

1
ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support.ADMETlab 3.0：一个更新的全面在线 ADMET 预测平台，具有更广泛的覆盖范围、更高的性能、API 功能和决策支持。
Nucleic Acids Res. 2024 Jul 5;52(W1):W422-W431. doi: 10.1093/nar/gkae236.
2
Brazilin is a natural product inhibitor of the NLRP3 inflammasome.巴西苏木素是NLRP3炎性小体的一种天然产物抑制剂。
iScience. 2024 Jan 19;27(2):108968. doi: 10.1016/j.isci.2024.108968. eCollection 2024 Feb 16.
3
Fluorescent-Based Neurotransmitter Sensors: Present and Future Perspectives.
基于荧光的神经递质传感器：现状和未来展望。
Biosensors (Basel). 2023 Nov 30;13(12):1008. doi: 10.3390/bios13121008.
4
Brazilin-7-acetate, a novel potential drug of Parkinson's disease, hinders the formation of α-synuclein fibril, mitigates cytotoxicity, and decreases oxidative stress.巴西红厚壳素-7-醋酸酯，一种新型潜在的帕金森病药物，可阻碍α-突触核蛋白纤维的形成，减轻细胞毒性，并降低氧化应激。
Eur J Med Chem. 2024 Jan 15;264:115965. doi: 10.1016/j.ejmech.2023.115965. Epub 2023 Nov 23.
5
The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery.从药物发现中ADME评价角度看计算机模拟模型的趋势与未来展望
Pharmaceutics. 2023 Nov 12;15(11):2619. doi: 10.3390/pharmaceutics15112619.
6
Brazilin from L. as a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor: Pharmacophore-Based Virtual Screening, Molecular Docking, and Studies.来自苏木的巴西苏木素作为一种前蛋白转化酶枯草杆菌蛋白酶/九型前蛋白转化酶（PCSK9）抑制剂：基于药效团的虚拟筛选、分子对接及研究
Adv Pharmacol Pharm Sci. 2023 Oct 11;2023:5932315. doi: 10.1155/2023/5932315. eCollection 2023.
7
Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Death.源自白前酮的高异黄酮通过细胞周期阻滞和非半胱天冬酶依赖性细胞死亡抑制乳腺癌细胞生长。
Biomol Ther (Seoul). 2023 Sep 1;31(5):526-535. doi: 10.4062/biomolther.2023.057. Epub 2023 May 25.
8
Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization.可溶性环氧化物水解酶表达下调抑制小鼠脉络膜新生血管。
Int J Mol Sci. 2022 Dec 9;23(24):15595. doi: 10.3390/ijms232415595.
9
Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L.苏木酮A：一种从苏木心材中提取的具有双重抗炎和抗氧化活性的天然磷酸二酯酶4抑制剂
J Ethnopharmacol. 2023 Mar 25;304:116020. doi: 10.1016/j.jep.2022.116020. Epub 2022 Dec 16.
10
Phenotypic drug discovery: recent successes, lessons learned and new directions.表型药物发现：近期的成功、经验教训和新方向。
Nat Rev Drug Discov. 2022 Dec;21(12):899-914. doi: 10.1038/s41573-022-00472-w. Epub 2022 May 30.