Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Department of Cell and Molecular Biology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Int J Mol Sci. 2024 Jul 9;25(14):7535. doi: 10.3390/ijms25147535.
This study provides a comparative analysis of 243 Methicillin-resistant (MRSA) isolated strains from Greece and Romania, focusing on their epidemiology and antibiotic resistance patterns. Laboratory procedures included phenotypic and automated identification methods, susceptibility testing, DNA isolation, and PCR for detecting antibiotic resistance genes (, ). Our study results show significant regional differences. In both regions, males have higher MRSA infection rates than females, but the percentages vary. Greece has a higher incidence of MRSA in younger age groups compared to Romania. The majority of MRSA infections occur in inpatient settings in both countries, highlighting the necessity for enhanced infection control measures. Antibiotic resistance profiles reveal higher resistance to several antibiotics in Greece compared to Romania. A molecular analysis shows a widespread distribution of antibiotic resistance genes among MRSA isolates in Greece. These results highlight the necessity for accomplished preventive strategies and optimized treatment protocols.
本研究对来自希腊和罗马尼亚的 243 株耐甲氧西林金黄色葡萄球菌(MRSA)分离株进行了比较分析,重点研究了它们的流行病学和抗生素耐药模式。实验室程序包括表型和自动化鉴定方法、药敏试验、DNA 分离和 PCR 检测抗生素耐药基因(、)。我们的研究结果显示出显著的地区差异。在这两个地区,男性的 MRSA 感染率高于女性,但百分比有所不同。与罗马尼亚相比,希腊的年轻人群中 MRSA 感染的发生率更高。两国的大多数 MRSA 感染发生在住院患者中,这突出了加强感染控制措施的必要性。抗生素耐药谱显示,与罗马尼亚相比,希腊的多种抗生素耐药性更高。分子分析显示,希腊的 MRSA 分离株中抗生素耐药基因广泛分布。这些结果强调了制定完善的预防策略和优化治疗方案的必要性。