Department of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj, 8 Victor Babes, Street, 400012 Cluj-Napoca, Romania.
Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania.
Int J Mol Sci. 2024 Jul 12;25(14):7646. doi: 10.3390/ijms25147646.
Chronic kidney disease (CKD) causes specific hormonal disturbances, such as variations in leptin and testosterone levels and function. These disturbances can promote errors in signaling interaction and cellular information processing and can be implicated in the pathogenesis of atherosclerosis. This study investigates the factors that affect leptin in CKD patients and examines how leptin is related to markers of vascular disease. We conducted a cross-sectional study of 162 patients with CKD in pre-dialysis and dialysis stages. We recorded clinical and laboratory data, including leptin, testosterone, and subclinical atherosclerosis markers like brachial-ankle pulse wave velocity (ba PWV) in pre-dialysis CKD patients and flow-mediated vasodilation (FMD) and nitroglycerin-mediated vasodilation (NMD) in hemodialysis (HD) patients. Leptin was significantly correlated with testosterone in CKD pre-dialysis stages ( < 0.001) and also in HD ( = 0.026), with adipose tissue mass in pre-dialysis stages ( < 0.001), and also in HD ( < 0.001). In women HD patients, leptin correlated with NMD ( = 0.039; r = -0.379); in all HD patients, leptin correlated with C reactive protein ( = 0.007; r = 0.28) and parathormone ( = 0.039; r = -0.220). Our research emphasizes the connection between leptin, adipose tissue, and testosterone in all stages of CKD. Leptin was associated with NMD in HD women and correlated with inflammatory syndrome and parathyroid hormone in all HD patients.
慢性肾脏病（CKD）导致特定的激素紊乱，如瘦素和睾酮水平和功能的变化。这些紊乱会促进信号交互和细胞信息处理中的错误，并可能与动脉粥样硬化的发病机制有关。本研究调查了影响 CKD 患者瘦素的因素，并研究了瘦素与血管疾病标志物的关系。我们对 162 例处于透析前和透析阶段的 CKD 患者进行了横断面研究。我们记录了临床和实验室数据，包括透析前 CKD 患者的瘦素、睾酮和亚临床动脉粥样硬化标志物，如肱踝脉搏波速度（ba PWV），以及血液透析（HD）患者的血流介导的血管舒张（FMD）和硝酸甘油介导的血管舒张（NMD）。瘦素与 CKD 透析前阶段的睾酮呈显著相关（<0.001），与 HD 也呈显著相关（=0.026），与透析前阶段的脂肪组织质量呈显著相关（<0.001），与 HD 也呈显著相关（<0.001）。在女性 HD 患者中，瘦素与 NMD 呈正相关（=0.039；r=-0.379）；在所有 HD 患者中，瘦素与 C 反应蛋白（=0.007；r=0.28）和甲状旁腺激素（=0.039；r=-0.220）呈正相关。我们的研究强调了瘦素、脂肪组织和睾酮在 CKD 所有阶段之间的联系。瘦素与 HD 女性的 NMD 相关，与所有 HD 患者的炎症综合征和甲状旁腺激素相关。
