Departamento de Ciencias de la Salud, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos 47620, Mexico.
Instituto de Investigación de Cáncer en la Infancia y Adolescencia, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Guadalajara 44340, Mexico.
Int J Mol Sci. 2024 Jul 20;25(14):7934. doi: 10.3390/ijms25147934.
Gastric cancer (GC) remains a significant global health challenge, with high mortality rates, especially in developing countries. Current treatments are invasive and have considerable risks, necessitating the exploration of safer alternatives. Quercetin (QRC), a flavonoid present in various plants and foods, has demonstrated multiple health benefits, including anticancer properties. This study investigated the therapeutic potential of QRC in the treatment of GC. We utilized advanced molecular techniques to assess the impact of QRC on GC cells, examining its effects on cellular pathways and gene expression. Our findings indicate that QRC significantly inhibits GC cell proliferation and induces apoptosis, suggesting its potential as a safer therapeutic option for GC treatment. Further research is required to validate these results and explore the clinical applications of QRC in cancer therapy.
胃癌(GC)仍然是一个重大的全球健康挑战,其死亡率很高,尤其是在发展中国家。目前的治疗方法具有侵入性且风险较大,因此需要探索更安全的替代方法。槲皮素(QRC)是一种存在于各种植物和食物中的类黄酮,具有多种健康益处,包括抗癌特性。本研究探讨了 QRC 在治疗 GC 中的治疗潜力。我们利用先进的分子技术来评估 QRC 对 GC 细胞的影响,研究其对细胞途径和基因表达的影响。我们的研究结果表明,QRC 可显著抑制 GC 细胞的增殖并诱导细胞凋亡,这表明其作为 GC 治疗更安全的治疗选择的潜力。需要进一步的研究来验证这些结果,并探索 QRC 在癌症治疗中的临床应用。