Teng Wendi, Zhou Zixiao, Cao Jinxuan, Guo Qing
Key Laboratory of Geriatric Nutrition and Health, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
State Key Laboratory of Food Nutrition and Safety, School of Food Science and Technology, Tianjin University of Science and Technology, Tianjin 300457, China.
Foods. 2024 Jul 16;13(14):2226. doi: 10.3390/foods13142226.
Bioactive compounds have drawn much attention according to their various health benefits. However, poor dissolvability, low stability and limited bioavailability largely narrow their applications. Although a variety of nontoxic ingredients have been rapidly developed as vehicles to deliver bioactive compounds in the last few years, most of them are non-bioactive. Pentacyclic triterpenoids, owing to their unique self-assembly and co-assembly behaviors and different physiological functions, can construct bioactive carriers due to their higher biodegradability, biocompatibility and lower toxicity. In this paper, the basic classification, biological activities and physicochemical properties of pentacyclic triterpenoids were summarized. Additionally, applications of self-assembled and co-assembled pentacyclic triterpenoids as bioactive delivery systems to load bioactive components and future research directions were discussed. This study emphasizes the potential of pentacyclic triterpenoids as bioactive delivery systems, offering a new perspective for constructing self- or co-assemblies for further synergetic biological applications.
生物活性化合物因其多种健康益处而备受关注。然而，溶解性差、稳定性低和生物利用度有限在很大程度上限制了它们的应用。尽管在过去几年中，各种无毒成分作为递送生物活性化合物的载体迅速发展，但其中大多数是无生物活性的。五环三萜类化合物由于其独特的自组装和共组装行为以及不同的生理功能，因其具有更高的生物降解性、生物相容性和更低的毒性，能够构建生物活性载体。本文总结了五环三萜类化合物的基本分类、生物活性和理化性质。此外，还讨论了自组装和共组装五环三萜类化合物作为生物活性递送系统用于负载生物活性成分的应用以及未来的研究方向。本研究强调了五环三萜类化合物作为生物活性递送系统的潜力，为构建自组装或共组装体系以实现进一步的协同生物应用提供了新的视角。
