Plastic Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Departments of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00118 Rome, Italy.
Medicina (Kaunas). 2024 Jul 11;60(7):1121. doi: 10.3390/medicina60071121.
: The facial skin defects associated with aging are common concerns in the aging population. Hyaluronic-acid-based intradermal gels have established themselves as safe and effective treatments for addressing these concerns. Recently developed enriched products aim to enhance the efficacy of these gels, yet their effectiveness lacks thorough validation in the existing literature. : In this retrospective analysis, we investigated the outcomes of intradermal gel treatments in 103 patients with soft tissue defects. This study included three groups: 35 patients received amino-acid-enriched hyaluronic acid gel, another 35 were treated with hydroxyapatite-enriched hyaluronic acid gel, and the remaining 33 underwent hyaluronic acid treatment only. The efficacy of the treatments was assessed using the Global Aesthetic Improvement Scale (GAIS) score, while patient satisfaction was gauged through a detailed questionnaire. Any adverse event was monitored. : The treatments demonstrated remarkable efficacy, as evidenced by mean GAIS scores of 1.714 points for those treated with amino acid-enriched hyaluronic acid gel, 1.886 points for individuals receiving hydroxyapatite-enriched hyaluronic acid gel, and 1.697 for those treated with hyaluronic acid alone, all showing statistical significance ( < 0.0001). Patient satisfaction was very high. Significantly, there were no recorded instances of major adverse events. : Hyaluronic gels, particularly those enriched with amino acids and hydroxyapatite, are effective and safe interventions for addressing facial skin aging defects. They serve as valuable tools in mitigating age-related blemishes and contribute to the overall improvement of skin aesthetics.
: 与衰老相关的面部皮肤缺陷是老龄化人群普遍关注的问题。基于透明质酸的真皮内凝胶已被证明是安全有效的治疗方法，可以解决这些问题。最近开发的富含成分的产品旨在提高这些凝胶的疗效，但它们的有效性在现有文献中缺乏充分验证。 : 在这项回顾性分析中，我们调查了 103 例软组织缺损患者真皮内凝胶治疗的结果。该研究包括三组：35 例患者接受氨基酸增强型透明质酸凝胶治疗，35 例患者接受羟基磷灰石增强型透明质酸凝胶治疗，其余 33 例患者仅接受透明质酸治疗。通过全球美学改善量表（GAIS）评分评估治疗效果，通过详细问卷评估患者满意度。监测任何不良事件。 : 治疗效果显著，接受氨基酸增强型透明质酸凝胶治疗的患者平均 GAIS 评分为 1.714 分，接受羟基磷灰石增强型透明质酸凝胶治疗的患者平均 GAIS 评分为 1.886 分，接受透明质酸单独治疗的患者平均 GAIS 评分为 1.697 分，均具有统计学意义（<0.0001）。患者满意度非常高。值得注意的是，没有记录到重大不良事件。 : 透明质酸凝胶，特别是富含氨基酸和羟基磷灰石的凝胶，是治疗面部皮肤衰老缺陷的有效且安全的干预措施。它们是减轻与年龄相关的瑕疵的有价值工具，并有助于整体改善皮肤美学。
