Department of Experimental Vascular Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.
Nutrients. 2024 Jul 19;16(14):2322. doi: 10.3390/nu16142322.
The human microbiome functions as a separate organ in a symbiotic relationship with the host. Disruption of this host-microbe symbiosis can lead to serious health problems. Modifications to the composition and function of the microbiome have been linked to changes in host metabolic outcomes. Industrial lifestyles with high consumption of processed foods, alcoholic beverages and antibiotic use have significantly altered the gut microbiome in unfavorable ways. Therefore, understanding the causal relationship between the human microbiome and host metabolism will provide important insights into how we can better intervene in metabolic health. In this review, I will discuss the potential use of the human microbiome as a therapeutic target to improve host metabolism.
人类微生物组与宿主之间存在共生关系，其功能类似于一个独立的器官。这种宿主-微生物共生关系的破坏可能会导致严重的健康问题。微生物组的组成和功能的改变与宿主代谢结果的变化有关。工业化的生活方式，包括大量食用加工食品、含酒精的饮料和使用抗生素，已经以不利的方式显著改变了肠道微生物组。因此，了解人类微生物组与宿主代谢之间的因果关系将为我们提供重要的见解，了解如何更好地干预代谢健康。在这篇综述中，我将讨论将人类微生物组作为一种治疗靶点来改善宿主代谢的潜在用途。
