The Key Laboratory of Animal Disease and Human Health of Sichuan Province, The Teaching Animal Hospital, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071, China.
Nutrients. 2024 Jul 20;16(14):2357. doi: 10.3390/nu16142357.
Plant Extracts (PE) are natural substances extracted from plants, rich in various bioactive components. Exploring the molecular mechanisms and interactions involved in the vascular protective effects of PE is beneficial for the development of further strategies to protect aging blood vessels. For this review, the content was obtained from scientific databases such as PubMed, China National Knowledge Infrastructure (CNKI), and Google Scholar up to July 2024, using the search terms "Plant extracts", "oxidative stress", "vascular aging", "endothelial dysfunction", "ROS", and "inflammation". This review highlighted the effects of PE in protecting aging blood vessels. Through pathways such as scavenging reactive oxygen species, activating antioxidant signaling pathways, enhancing respiratory chain complex activity, inhibiting mitochondrial-reactive oxygen species generation, improving nitric oxide bioavailability, downregulating the secretion of inflammatory factors, and activating sirtuins 1 and Nrf2 signaling pathways, it can improve vascular structural and functional changes caused by age-related oxidative stress, mitochondrial dysfunction, and inflammation due to aging, thereby reducing the incidence of age-related cardiovascular diseases.
植物提取物 (PE) 是从植物中提取的天然物质，富含各种生物活性成分。探索 PE 对血管保护作用的分子机制和相互作用，有利于进一步制定保护老化血管的策略。为此，本综述的内容截至 2024 年 7 月，通过 PubMed、中国知网 (CNKI) 和谷歌学术等科学数据库，使用“植物提取物”“氧化应激”“血管老化”“内皮功能障碍”“ROS”和“炎症”等检索词进行检索。本综述强调了 PE 保护老化血管的作用。通过清除活性氧、激活抗氧化信号通路、增强呼吸链复合体活性、抑制线粒体活性氧生成、提高一氧化氮生物利用度、下调炎症因子分泌、激活 Sirtuins 1 和 Nrf2 信号通路等途径，可以改善与年龄相关的氧化应激、线粒体功能障碍和炎症引起的血管结构和功能变化，从而降低与年龄相关的心血管疾病的发病率。
