Wu Xue, Shen Jiuheng, Zhong Youxiu, Zhao Xian, Zhou Wantong, Gao Peifen, Wang Xudong, An Wenlin
China National Biotech Group (CNBG), Sinopharm Group, National Vaccine & Serum Institute (NVSI), No. 38 Jing Hai Second Road, Beijing 101111, China.
Pharmaceutics. 2024 Jul 11;16(7):930. doi: 10.3390/pharmaceutics16070930.
Exosomes are small membrane vesicles in a cell culture. They are secreted by most cells and originate from the endosomal pathway. A variety of proteins, lipids, and genetic materials have been shown to be carried by exosomes. Once taken up by neighboring or distant cells, the bioactive compounds in exosomes can regulate the condition of recipient cells. Typically, producing exosomes in large quantities requires cell culture, resulting in high production costs. However, exosomes are abundant in milk and can be isolated on a large scale at a low cost. In our study, we found that milk exosomes can promote the synthesis and reconstruction of stratum corneum lipids, enhance skin barrier function, and provide greater protection for the skin. Furthermore, milk exosomes have anti-inflammatory properties that can reduce skin irritation, redness, and other symptoms, giving immediate relief. They also exhibit antioxidant activity, which helps neutralize free radicals and slows down the skin aging process. Additionally, milk exosomes inhibit melanin production, aiding in skin whitening. Ongoing research has uncovered the benefits of milk exosomes for skin improvement and their application in cosmetics, skin healthcare, and other fields, and these applications are continuing to expand.
外泌体是细胞培养物中的小膜泡。它们由大多数细胞分泌，起源于内体途径。已证明外泌体携带多种蛋白质、脂质和遗传物质。一旦被邻近或远处的细胞摄取，外泌体中的生物活性化合物就可以调节受体细胞的状态。通常，大量生产外泌体需要细胞培养，导致生产成本高昂。然而，牛奶中富含外泌体，可以低成本大规模分离。在我们的研究中，我们发现牛奶外泌体可以促进角质层脂质的合成和重建，增强皮肤屏障功能，并为皮肤提供更好的保护。此外，牛奶外泌体具有抗炎特性，可以减轻皮肤刺激、发红和其他症状，立即缓解。它们还具有抗氧化活性，有助于中和自由基并减缓皮肤衰老过程。此外，牛奶外泌体抑制黑色素生成，有助于皮肤美白。正在进行的研究揭示了牛奶外泌体对改善皮肤的益处及其在化妆品、皮肤保健和其他领域的应用，并且这些应用正在不断扩大。
