Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin Province, China.
Department of Cell Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin Province, China.
Nutr Cancer. 2024;76(10):885-901. doi: 10.1080/01635581.2024.2383336. Epub 2024 Jul 26.
is a Chinese herb known as "yin and yang fire," first mentioned in the Compendium of Materia Medica. Many of the proprietary Chinese medicines used in clinical practice contain as an ingredient, and its main active constituents include icariin, icaritin, and icariside II, among others. In addition to its traditional use in treating fatigue and sexual problems, modern research has confirmed that the main bioactive compounds in have pharmacological effects such as antidepressant, antibacterial, antiviral, antioxidant, and anti-inflammatory properties, as well as inhibiting bone destruction, promoting bone growth, improving immune regulation and protecting the cardio-cerebral vascular system. With the continuous development of extraction and purification techniques, the development and use of bioactive compounds in have significantly progressed, and the anticancer effect has received widespread attention. Since natural herbs have few side effects on the human body and do not easily develop drug resistance, they have long been the direction of research in cancer treatment. This review summarizes the latest research on the anticancer effects of and its extracts, describes the bioactive compounds, pharmacological efficacy, and antitumor mechanism of , and gives a new view on the administration and development of .
淫羊藿是一种中国草药，被称为“阴阳火”，最早在《本草纲目》中提到。许多在临床实践中使用的中药制剂都含有淫羊藿作为一种成分，其主要的活性成分包括淫羊藿苷、淫羊藿素和淫羊藿次苷 II 等。除了传统上用于治疗疲劳和性功能问题外，现代研究已经证实，淫羊藿中的主要生物活性化合物具有抗抑郁、抗菌、抗病毒、抗氧化和抗炎作用，以及抑制骨质破坏、促进骨生长、改善免疫调节和保护心脑血管系统的作用。随着提取和纯化技术的不断发展，淫羊藿中生物活性化合物的开发和利用取得了显著进展，其抗癌作用受到了广泛关注。由于天然草药对人体的副作用较小，不易产生耐药性，因此一直是癌症治疗研究的方向。本综述总结了淫羊藿及其提取物的最新抗癌作用研究，描述了淫羊藿的生物活性化合物、药理作用和抗肿瘤机制，并为其给药和开发提供了新的思路。
