Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
Department of Orthopaedics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
Geriatr Nurs. 2024 Sep-Oct;59:250-255. doi: 10.1016/j.gerinurse.2024.07.001. Epub 2024 Jul 26.
Postmenopausal osteoporosis and fractures are widely prevalent. However, the relationship of body composition with bone health in this population remains unclear. The aim of this study was to investigate the association of body composition with bone mineral density (BMD) and 10-year probability of hip fracture in postmenopausal women.
This is a cross-sectional study. A total of 1285 subjects were included in our study. Body composition and BMD were assessed using dual-energy X-ray densitometry. The 10-year probability of hip fracture of participants was calculated. All participants were categorized into four groups: sarcopenic-obese (SO) group, sarcopenic-nonobese (S) group, nonsarcopenic-obese (O) group, or nonsarcopenic-nonobese control (C) group. Multivariate analyses and binary logistic regression were conducted to explore the relationship of body composition with BMD and 10-year probability of hip fracture.
Participants in S group were 2.8, 4.7 and 4.8 times more likely to develop osteoporosis in the lumbar spine, the total hip and femoral neck sites, respectively. Lean mass was positively correlated with BMD, wherein lumbar spine BMD was significantly affected by appendicular lean mass, while total hip BMD and femoral neck BMD were mainly influenced by trunk lean mass. Total fat mass was positively associated with total hip and femoral neck BMD, but not with lumbar spine BMD. A significant correlation was observed between lean mass and 10-year probability of hip fracture.
Changes in body composition in postmenopausal women could affect bone health. A decrease in regional lean mass may be associated with an increased risk of osteoporosis and fractures.
绝经后骨质疏松症和骨折较为普遍。然而，该人群的身体成分与骨骼健康的关系仍不清楚。本研究旨在调查绝经后妇女身体成分与骨密度（BMD）和 10 年髋部骨折概率的关系。
这是一项横断面研究。共纳入 1285 名受试者。使用双能 X 射线吸收法评估身体成分和 BMD。计算参与者髋部骨折的 10 年概率。所有参与者分为 4 组：肌少性肥胖（SO）组、肌少性非肥胖（S）组、非肌少性肥胖（O）组或非肌少性非肥胖对照组（C）。进行多变量分析和二元逻辑回归以探讨身体成分与 BMD 和 10 年髋部骨折概率的关系。
S 组患者发生腰椎、全髋和股骨颈部位骨质疏松的风险分别是对照组的 2.8、4.7 和 4.8 倍。瘦体重与 BMD 呈正相关，其中腰椎 BMD 受四肢瘦体重显著影响，而全髋 BMD 和股骨颈 BMD 主要受躯干瘦体重影响。总脂肪量与全髋和股骨颈 BMD 呈正相关，但与腰椎 BMD 无关。瘦体重与 10 年髋部骨折概率之间存在显著相关性。
绝经后妇女身体成分的变化可能会影响骨骼健康。局部瘦体重的减少可能与骨质疏松症和骨折风险增加有关。
