Zhang Fan, Xiong Qunli, Wang Min, Cao Ximing, Zhou Congya
Department of Oncology, Shaanxi Provincial People's Hospital, No 256 Youyi West Road, Xi'an, 710068, Shaanxi, China.
Department of Abdominal Oncology, West China Hospital, Sichuan University, No 37 Guoxue Lane, Chengdu, 610041, Sichuan, China.
Transl Oncol. 2024 Oct;48:102066. doi: 10.1016/j.tranon.2024.102066. Epub 2024 Jul 26.
Far upstream element-binding protein 1 (FUBP1) is a single-stranded nucleic acid-binding protein that binds to the Far Upstream Element (FUSE) sequence and is involved in important biological processes, including DNA transcription, RNA biogenesis, and translation. Recent studies have highlighted the significance of aberrant expression or mutations in FUBP1 in the development of various tumors, with FUBP1 overexpression often indicating oncogenic roles in different tumor types. However, it is worth noting that recent research has discovered its tumor-suppressive role in cancer, which is not yet fully understood and appears to be tissue- or context-dependent. This review summarizes the association between FUBP1 and diverse cancers and discusses the functions of FUBP1 in cancer. In addition, this review proposes potential clinical implications and outlines future research directions to pave the way for the development of targeted therapeutic strategies focusing on FUBP1.
远上游元件结合蛋白1（FUBP1）是一种单链核酸结合蛋白，它与远上游元件（FUSE）序列结合，并参与重要的生物学过程，包括DNA转录、RNA生物合成和翻译。最近的研究强调了FUBP1异常表达或突变在各种肿瘤发生发展中的重要性，FUBP1过表达通常在不同肿瘤类型中表明具有致癌作用。然而，值得注意的是，最近的研究发现了它在癌症中的肿瘤抑制作用，这一点尚未完全了解，而且似乎取决于组织或环境。这篇综述总结了FUBP1与多种癌症之间的关联，并讨论了FUBP1在癌症中的功能。此外，本综述提出了潜在的临床意义，并概述了未来的研究方向，为开发针对FUBP1的靶向治疗策略铺平道路。
