Gasparetto Juliano, Bressianini Jurkonis Leandro, Ramos Dantas Leticia, Hansen Suss Paula, Francisco Tuon Felipe
Laboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil; Intensive Care Unit, Hospital Universitario Cajuru, Pontificia Universidade Católica do Paraná, Curitiba, Brazil.
Laboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Rev Argent Microbiol. 2024 Oct-Dec;56(4):359-363. doi: 10.1016/j.ram.2024.05.004. Epub 2024 Jul 26.
Ventilator-associated pneumonia (VAP) is one of the most common causes of nosocomial infections. The aim of this study was to evaluate the antimicrobial and anti-biofilm activity of an in-house low-cost tracheostomy tube impregnated with chlorhexidine and violet crystal. The impregnated tracheostomy tubes demonstrated antimicrobial activity, including for multidrug-resistant bacteria. Fourteen patients were evaluated. During ventilation, VAP occurred in one patient in the coated group and in three patients in the control group (p=0.28). A reduction of biofilm cells was observed. This study provides preliminary evidence to support that the antiseptic impregnation of a tracheostomy tube provides significant antimicrobial activity.
呼吸机相关性肺炎（VAP）是医院感染最常见的原因之一。本研究的目的是评估一种内部自制的、浸渍有氯己定和结晶紫的低成本气管造口管的抗菌和抗生物膜活性。浸渍后的气管造口管表现出抗菌活性，包括对多重耐药菌的活性。对14名患者进行了评估。通气期间，涂层组有1名患者发生VAP，对照组有3名患者发生VAP（p = 0.28）。观察到生物膜细胞有所减少。本研究提供了初步证据，支持气管造口管的抗菌浸渍具有显著的抗菌活性。
