Fan Yan, Meng Yuan, Hu Xingwei, Liu Jianhua, Qin Xiaosong
Department of Laboratory Medicine, Liaoning Clinical Research Center for Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110122, China.
Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, Liaoning Province, China.
Cancer Cell Int. 2024 Jul 27;24(1):268. doi: 10.1186/s12935-024-03425-y.
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that is induced and regulated by multiple factors during inflammation in enteritis, pneumonia, asthma, arthritis, and other diseases. It is associated with the deterioration of the inflammatory environment in tissues with chronic inflammation caused by microbial infection or autoimmune diseases. The expression of CHI3L1 expression is upregulated in several malignant tumors, underscoring the crucial role of chronic inflammation in the initiation and progression of cancer. While the precise mechanism connecting inflammation and cancer is unclear, the involvement of CHI3L1 is involved in chronic inflammation, suggesting its role as a contributing factor to in the link between inflammation and cancer. CHI3L1 can aggravate DNA oxidative damage, induce the cancerous phenotype, promote the development of a tumor inflammatory environment and angiogenesis, inhibit immune cells, and promote cancer cell growth, invasion, and migration. Furthermore, it participates in the initiation of cancer progression and metastasis by binding with transmembrane receptors to mediate intracellular signal transduction. Based on the current research on CHI3L1, we explore introduce the receptors that interact with CHI3L1 along with the signaling pathways that may be triggered during chronic inflammation to enhance tumorigenesis and progression. In the last section of the article, we provide a brief overview of anti-inflammatory therapies that target CHI3L1.
几丁质酶-3样蛋白1（CHI3L1）是一种分泌型糖蛋白，在肠炎、肺炎、哮喘、关节炎和其他疾病的炎症过程中，受多种因素诱导和调节。它与由微生物感染或自身免疫性疾病引起的慢性炎症组织中炎症环境的恶化有关。CHI3L1的表达在几种恶性肿瘤中上调，突出了慢性炎症在癌症发生和发展中的关键作用。虽然连接炎症和癌症的确切机制尚不清楚，但CHI3L1参与慢性炎症，表明其在炎症与癌症之间的联系中作为一个促成因素的作用。CHI3L1可加重DNA氧化损伤，诱导癌表型，促进肿瘤炎症环境的发展和血管生成，抑制免疫细胞，并促进癌细胞生长、侵袭和迁移。此外，它通过与跨膜受体结合介导细胞内信号转导，参与癌症进展和转移的起始。基于目前对CHI3L1的研究，我们探讨介绍与CHI3L1相互作用的受体以及在慢性炎症过程中可能触发的信号通路，以增强肿瘤发生和进展。在文章的最后一部分，我们简要概述了针对CHI3L1的抗炎治疗。
