Department of Engineering for Innovation, University of Salento, via per Monteroni, Lecce, Italy.
Department of Engineering for Innovation, University of Salento, via per Monteroni, Lecce, Italy; Typeone Biomaterials S.r.l., Via Europa 167, 73021 Calimera, Lecce, Italy.
Int J Biol Macromol. 2024 Oct;277(Pt 2):134220. doi: 10.1016/j.ijbiomac.2024.134220. Epub 2024 Jul 26.
In recent years, significant academic and commercial interest has focused on collagen derived from horse tendons, with potential applications across diverse sectors such as medicine, pharmaceuticals, and cosmetics. Nano collagen, with its enhanced wound penetration, improved cell contact, and heightened cellular regeneration and repair capabilities due to its high surface area, holds promise for a wide range of applications. In this study, we present a novel method for producing nano collagen from the equine tendon. Our approach is characterized by its speed, affordability, simplicity and environmentally friendly nature, with precise temperature-control to prevent collagen denaturation. We conducted a comprehensive characterization of the obtained samples, including assessments of morphology, chemical and thermal properties, particle size distribution and biocompatibility. Importantly, our results indicate improvements in thermal stability, and surface roughness of nano collagen, while preserving its molecular weight. These advancements expand the potential applications of nano collagen in various fields.
近年来，马肌腱来源的胶原蛋白引起了学术界和商业界的极大关注，其潜在应用领域广泛，涵盖医学、制药和化妆品等多个领域。纳米胶原由于其高表面积，具有增强的伤口穿透性、改善的细胞接触性以及更高的细胞再生和修复能力，有望在广泛的应用中得到应用。在这项研究中，我们提出了一种从马肌腱中生产纳米胶原的新方法。我们的方法具有速度快、成本低、简单和环保的特点，并且通过精确的温度控制来防止胶原蛋白变性。我们对获得的样品进行了全面的表征，包括形态、化学和热性能、粒径分布和生物相容性的评估。重要的是，我们的结果表明纳米胶原的热稳定性和表面粗糙度得到了改善，同时保持了其分子量。这些进展扩大了纳米胶原在各个领域的潜在应用。
