State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, PR China.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China; School of Life Science, Lanzhou University, Lanzhou 730000, PR China.
Int J Biol Macromol. 2024 Jun;272(Pt 1):132857. doi: 10.1016/j.ijbiomac.2024.132857. Epub 2024 Jun 2.
Skin damage caused by excessive UV radiation has gradually become one of the most prevalent skin diseases. Collagen has gradually found applications in the treatment of UV-damaged skin; however, their high molecular weight greatly limits their capacity to permeate the skin barrier and repair the damaged skin. Nano collagen has garnered growing attentions in the mimicking of collagen; while the investigation of its skin permeability and wound-healing capability remains vacancies. Herein, we have for the first time created a highly biocompatible and bioactive transdermal nano collagen demonstrating remarkable transdermal capacity and repair efficacy for UV-damaged skin. The transdermal nano collagen exhibited a stable triple-helix structure, effectively promoting the adhesion and proliferation of fibroblasts. Notably, the transdermal nano collagen displayed exceptional penetration capabilities, permeating fibroblast and healthy skin. Combo evaluations revealed that the transdermal nano collagen contributed to recovering the intensity and TEWL values of UV-damaged skin to normal level. Histological analysis further indicated that transdermal nano collagen significantly accelerated the repair of damaged skin by promoting the collagen regeneration and fibroblasts activation. This highly biocompatible and bioactive transdermal nano collagen provides a novel substituted strategy for the transdermal absorption of collagen, indicating great potential applications in cosmetics and dermatology.
由过量紫外线辐射引起的皮肤损伤逐渐成为最普遍的皮肤疾病之一。胶原蛋白逐渐被应用于治疗紫外线损伤的皮肤；然而，其高分子量极大地限制了其穿透皮肤屏障并修复受损皮肤的能力。纳米胶原在模拟胶原方面引起了越来越多的关注；然而，其皮肤渗透性和伤口愈合能力的研究仍存在空白。在此，我们首次构建了一种高度生物相容性和生物活性的透皮纳米胶原，显示出对紫外线损伤皮肤的优异透皮能力和修复功效。该透皮纳米胶原表现出稳定的三螺旋结构，有效促进成纤维细胞的黏附和增殖。值得注意的是，该透皮纳米胶原表现出优异的渗透能力，能够渗透进入成纤维细胞和健康皮肤。综合评估表明，透皮纳米胶原有助于将紫外线损伤皮肤的强度和 TEWL 值恢复至正常水平。组织学分析进一步表明，透皮纳米胶原通过促进胶原蛋白再生和成纤维细胞激活，显著加速受损皮肤的修复。这种高度生物相容性和生物活性的透皮纳米胶原为胶原的透皮吸收提供了一种新的替代策略，在化妆品和皮肤病学领域具有广阔的应用前景。
