Natural and Medical Sciences Research Center, University of Nizwa, 611, Oman.
Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran; Department of Biochemistry and Nutrition, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Int J Biol Macromol. 2024 Oct;278(Pt 1):134210. doi: 10.1016/j.ijbiomac.2024.134210. Epub 2024 Jul 26.
Diabetes mellitus is an increasingly prevalent metabolic disorder characterized by chronic hyperglycemia and impaired insulin action. Although the pathogenesis of diabetes is multifactorial, emerging evidence suggests that chronic low-grade inflammation plays a significant role in the development and progression of the disease. The cyclic GMP-AMP synthase (cGAS) and its downstream signaling pathway, the stimulator of interferon genes (STING), have recently gained attention in the field of diabetes research. This article aims to provide an overview of the role of cGAS-STING in diabetes, focusing on its involvement in the regulation of immune responses, inflammation, insulin resistance, and β-cell dysfunction. Understanding the contribution of cGAS-STING signaling in diabetes may lead to the development of targeted therapeutic strategies for this prevalent metabolic disorder. The results section presents key findings from multiple studies on the impact of STING in diabetes. It discusses the influence of STING on inflammation levels within a diabetic environment, its effect on insulin resistance, and its implications for the development and progression of diabetes. The cGAS-STING signaling pathway plays a crucial role in the development and progression of diabetes.
糖尿病是一种日益普遍的代谢紊乱疾病，其特征是慢性高血糖和胰岛素作用受损。虽然糖尿病的发病机制是多因素的，但新出现的证据表明，慢性低度炎症在疾病的发生和发展中起着重要作用。环鸟苷酸-腺苷酸合酶 (cGAS) 及其下游信号通路，干扰素基因刺激物 (STING)，在糖尿病研究领域引起了关注。本文旨在概述 cGAS-STING 在糖尿病中的作用，重点介绍其在调节免疫反应、炎症、胰岛素抵抗和 β 细胞功能障碍方面的作用。了解 cGAS-STING 信号在糖尿病中的作用可能会导致针对这种普遍代谢紊乱疾病的靶向治疗策略的发展。结果部分介绍了多项关于 STING 在糖尿病中影响的研究的关键发现。它讨论了 STING 在糖尿病环境中对炎症水平的影响、对胰岛素抵抗的影响以及对糖尿病的发展和进展的影响。cGAS-STING 信号通路在糖尿病的发生和发展中起着关键作用。
