Codron Philippe, Millecamps Stéphanie, Corcia Philippe
Centre de Référence sur la SLA d'Angers, Centre Hospitalier Universitaire d'Angers, Angers, France; Laboratoire de Neurobiologie et Neuropathologie, Centre Hospitalier Universitaire d'Angers, Angers, France; University of Angers, Inserm, CNRS, MITOVASC, SFR ICAT, Angers, France.
Sorbonne Université, Institut du Cerveau, Paris Brain Institute , ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, France.
Trends Mol Med. 2024 Dec;30(12):1097-1099. doi: 10.1016/j.molmed.2024.07.006. Epub 2024 Jul 27.
The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.
肌萎缩侧索硬化症（ALS）生物标志物的识别是疾病研究中的核心问题。在最近的一篇文章中，查特吉等人表明，富含转录激活反应DNA结合蛋白43（TDP-43）的血液细胞外囊泡（EVs）能够准确区分ALS患者与对照组，并且与疾病严重程度相关，为早期诊断和监测提供了一种有前景的生物标志物。
