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缺铁性贫血管理的进展:探索新型药物递送系统及未来展望

Advances in Iron Deficiency Anaemia Management: Exploring Novel Drug Delivery Systems and Future Perspectives.

作者信息

Saini Muskan, Trehan Karan, Thakur Shubham, Modi Anuj, Jain Subheet Kumar

机构信息

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.

Department of Pharmacy, Delhi Skill and Entrepreneurship University, Dwarka Campus, New Delhi, 110077, India.

出版信息

Curr Drug Deliv. 2024 Jul 25. doi: 10.2174/0115672018300804240426070552.

Abstract

Iron Deficiency Anaemia (IDA) is a prevalent global health issue characterized by inadequate iron levels in the body, leading to impaired red blood cell production and subsequent anaemia. Traditional treatment approaches for IDA, such as oral iron supplementation, often encounter challenges related to poor compliance, gastrointestinal side effects, and variable absorption rates. As a result, there is a growing interest in exploring novel drug delivery systems to enhance iron therapy efficacy and patient outcomes. This review discusses recent advances in IDA management, focusing on developing and utilizing innovative drug delivery systems for iron supplementation. Various strategies, including nanoformulations, microparticles, liposomes, and hydrogels, are explored for their potential to improve iron bioavailability, reduce adverse effects, and optimize therapeutic outcomes. Furthermore, promising strategies for the future management of IDA are explored, including the utilization of advanced technologies such as targeted drug delivery systems, controlled release mechanisms, and combination therapies. The integration of these novel drug delivery systems with advancements in diagnostics, personalized medicine, and patient-centered care holds great potential to revolutionize the management of IDA and improve the quality of life for individuals affected by this condition.

摘要

缺铁性贫血(IDA)是一个普遍存在的全球健康问题,其特征是体内铁水平不足,导致红细胞生成受损并随后引发贫血。IDA的传统治疗方法,如口服铁补充剂,常常面临依从性差、胃肠道副作用以及吸收率不一等挑战。因此,人们越来越有兴趣探索新型药物递送系统,以提高铁治疗的疗效和患者的治疗效果。本综述讨论了IDA管理方面的最新进展,重点关注开发和利用用于铁补充的创新药物递送系统。探讨了各种策略,包括纳米制剂、微粒、脂质体和水凝胶,以评估它们在提高铁生物利用度、减少不良反应和优化治疗效果方面的潜力。此外,还探索了IDA未来管理的有前景的策略,包括利用靶向药物递送系统、控释机制和联合疗法等先进技术。这些新型药物递送系统与诊断学、个性化医疗和以患者为中心的护理方面的进展相结合,极有可能彻底改变IDA的管理方式,并改善受这种疾病影响的个体的生活质量。

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