用于识别某些神经退行性疾病生物标志物的分子印迹聚合物。
Molecularly imprinted polymers for the recognition of biomarkers of certain neurodegenerative diseases.
作者信息
Pilvenyte Greta, Ratautaite Vilma, Boguzaite Raimonda, Samukaite-Bubniene Urte, Plausinaitis Deivis, Ramanaviciene Almira, Bechelany Mikhael, Ramanavicius Arunas
机构信息
Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology, Saulėtekio av. 3, LT-10257 Vilnius, Lithuania.
Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology, Saulėtekio av. 3, LT-10257 Vilnius, Lithuania; Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania.
出版信息
J Pharm Biomed Anal. 2023 May 10;228:115343. doi: 10.1016/j.jpba.2023.115343. Epub 2023 Mar 14.
The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to summarize the studies about electrochemical biosensors with molecularly imprinted polymers as sensitive and selective layers on the electrode to detect protein-based biomarkers of such neurodegenerative diseases as Alzheimer's disease, Parkinson's disease, and stress. The main attention in this article is focused on the detection methods of amyloid-β oligomers and p-Tau which are representative biomarkers for Alzheimer's disease, α-synuclein as the biomarker of Parkinson's disease, and α-amylase and lysozyme as the biomarkers of stress using molecular imprinting technology. The research methods, the application of different electrodes, the influence of the polymers, and the established detection limits are reviewed and compared.
血液、尿液、唾液、泪液等体液中生物标志物的出现可用于多种疾病的识别。本文旨在总结有关以分子印迹聚合物作为电极上的敏感和选择性层的电化学生物传感器的研究，以检测阿尔茨海默病、帕金森病和应激等神经退行性疾病基于蛋白质的生物标志物。本文主要关注使用分子印迹技术检测淀粉样β寡聚体和p- Tau（阿尔茨海默病的代表性生物标志物）、α-突触核蛋白（帕金森病的生物标志物）以及α-淀粉酶和溶菌酶（应激的生物标志物）的方法。对研究方法、不同电极的应用、聚合物的影响以及确定的检测限进行了综述和比较。
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