Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave. 9, 630090 Novosibirsk, Russia.
Department of Microbiology, Immunology and Virology, Novosibirsk State Medical University, Krasny Prospect 52, 630091 Novosibirsk, Russia.
Molecules. 2019 Jun 5;24(11):2126. doi: 10.3390/molecules24112126.
Synthesis of 1,2,3-triazole-substituted coumarins and also 1,2,3-triazolyl or 1,2,3-triazolylalk-1-inyl-linked coumarin-2,3-furocoumarin hybrids was performed by employing the cross-coupling and copper catalyzed azide-alkyne cycloaddition reaction approaches. The synthesized compounds were evaluated for their in vitro antibacterial activity against , , and bacterial strains. Coumarin-benzoic acid hybrids , and 3-((4-acetylamino-3-(methoxycarbonyl)phenyl)ethynyl)coumarin () showed promising activity against . strains, and the 1,2,3-triazolyloct-1-inyl linked coumarin-2,3-furocoumarin hybrid was endowed with high selectivity against and species. The in vitro antibacterial activity of , , and can potentially be compared with that of a number of modern antibiotic drugs used in the clinic, suggesting promising prospects for further research. A detailed study of the molecular interactions with the targeted protein MurB was performed using docking simulations and the obtained results are quite promising.
通过交叉偶联和铜催化叠氮-炔环加成反应方法，合成了 1,2,3-三唑取代香豆素以及 1,2,3-三唑基或 1,2,3-三唑基炔-1-基连接的香豆素-2,3-呋喃香豆素杂合体。合成的化合物被评估了它们对 、 、 和 细菌菌株的体外抗菌活性。香豆素-苯甲酸杂合体 、 和 3-((4-乙酰氨基-3-(甲氧基羰基)苯基)乙炔基)香豆素()对 表现出有希望的活性。菌株，而 1,2,3-三唑基辛-1-基连接的香豆素-2,3-呋喃香豆素杂合体对 和 种具有高选择性。和 的体外抗菌活性可能与临床上使用的许多现代抗生素药物相当，这表明进一步研究具有广阔的前景。使用对接模拟对与靶蛋白 MurB 的分子相互作用进行了详细研究，得到的结果非常有前途。
