Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100091, China.
School of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China.
ACS Sens. 2024 Aug 23;9(8):3958-3966. doi: 10.1021/acssensors.4c00705. Epub 2024 Jul 28.
Glaucoma is the world's second-leading irreversible eye disease causing blindness. Although the pathogenesis of glaucoma is not particularly well understood, high intraocular pressure (IOP) is widely recognized as a significant risk factor. In clinical practice, various devices have been used to measure IOP, but most of them cannot provide continuous measurements for a long time. To meet the needs of glaucoma patients who experience frequent fluctuations in the IOP and require constant monitoring, we fabricated an implantable piezoresistive IOP sensor based on microfluidic technology. The sensor has a sensitivity of 0.00257 Ω/mbar and demonstrates excellent linearity, stability, and repeatability. According to the calibration data, the average measurement error is ±0.5 mbar. We implanted it into the vitreous of a rabbit and successfully detected its IOP fluctuations. The sensor is simple in design, easy to fabricate, and can be used for long-term continuous IOP measurements. It presents a new approach for microfluidic-based IOP sensors and offers a novel method for the daily care of patients with glaucoma.
青光眼是全球第二大致盲性不可逆眼病。尽管青光眼的发病机制尚不完全清楚，但高眼压被广泛认为是一个重要的危险因素。在临床实践中，已经使用了各种设备来测量眼压，但大多数设备都不能长时间提供连续测量。为了满足眼压经常波动且需要持续监测的青光眼患者的需求，我们基于微流控技术制造了一种可植入的压阻式眼压传感器。该传感器的灵敏度为 0.00257 Ω/mbar，表现出优异的线性度、稳定性和可重复性。根据校准数据，平均测量误差为±0.5 mbar。我们将其植入兔子的玻璃体中，并成功地检测到了眼压波动。该传感器设计简单，易于制造，可用于长期连续眼压测量。它为基于微流控的眼压传感器提供了一种新方法，为青光眼患者的日常护理提供了一种新方法。
