Tareeva I E, Lazovskis I R
Ter Arkh. 1985;57(6):20-5.
The term tubulointerstitial nephropathy (TIN) means a renal disease, during which the tubules and interstice form a substrate of the primary injury or a substrate whose involvement is dominating in the disease clinical picture. The incidence of TIN is fairly high, with different etiology and pathogenesis. Drug, virus, bacterial and immune patterns are among the most common types of acute TIN. It is shown that the incidence of chronic drug TIN ranges from 0.2% among urban population to 0.6% among rural population. The incidence and gravity of renal injuries in hyperuricemia depend on the blood uric acid content. Study of the incidence and character of TIN in hypercalcemia in patients with sarcoidosis, hyperparathyrosis and multiple myeloma demonstrates the character of tubulointerstitial lesions to depend on the structure of paraprotein. In systemic lupus erythematosus, tubulointerstitial lesions are detected in 50% of cases. Such a comprehensive treatment of TIN opens up new vistas in the prophylaxis and therapy of this illness.
肾小管间质性肾病（TIN）这一术语指的是一种肾脏疾病，在此疾病过程中，肾小管和间质构成原发性损伤的基础，或者是其受累情况在疾病临床表现中占主导地位的基础。TIN的发病率相当高，病因和发病机制各不相同。药物、病毒、细菌和免疫型是急性TIN最常见的类型。研究表明，慢性药物性TIN的发病率在城市人口中为0.2%，在农村人口中为0.6%。高尿酸血症中肾损伤的发病率和严重程度取决于血尿酸含量。对结节病、甲状旁腺功能亢进和多发性骨髓瘤患者高钙血症中TIN的发病率和特征进行研究表明，肾小管间质病变的特征取决于副蛋白的结构。在系统性红斑狼疮中，50%的病例可检测到肾小管间质病变。对TIN的这种综合治疗为该疾病的预防和治疗开辟了新的前景。
