[Chronic tubulointerstitial nephritis (structure, pathogenesis, clinical picture and morphology)].

Based on the clinico-laboratory and intravital morphological examination of 104 patients and the reported data the authors recognize 6 versions of chronic tubulo-interstitial nephritis (TIN): idiopathic, drug-induced, dysplastic, dysmetabolic, secondary TIN associated with primary glomerulopathies and vasorenal hypertension, secondary TIN in the presence of a long-term ischemia. Discuss the features of each form, diagnostic criteria, a possible importance of TIN for the development of arterial hypertension. Emphasize the importance of recognizing TIN in patients with primary glomerulopathies to early specify the causes of the deterioration of the disease course. Discuss the problems of therapy.