Cheng Zhenyu, Nie Wenying, Leng Junhong, Yang Linfeng, Wang Yuanyuan, Li Xianglin, Guo Lingfei
School of Medical Imaging, Binzhou Medical University, Yantai, Shandong, China.
Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Front Neurol. 2024 Jul 12;15:1398009. doi: 10.3389/fneur.2024.1398009. eCollection 2024.
Cerebral small vessel disease (CSVD) is a prevalent vascular disorder that has been consistently associated with vascular cognitive impairment (VCI). The diagnosis of CSVD continues to rely on magnetic resonance imaging (MRI). Epidemiological data indicate that the characteristic MRI features of CSVD, including white matter hyperintensity (WMH) and lacunar infarction, are very common among individuals over 40 years of age in community studies. This prevalence poses a significant burden on many low- and middle-income families. The amygdala plays a crucial role in integrating sensory and associative information to regulate emotional cognition. Although many previous studies have linked alterations in the amygdala to various diseases, such as depression, there has been little research on CSVD-associated alterations in the amygdala due to the complexity of CSVD. In this paper, we summarize the various imaging features of CSVD and discuss the correlation between amygdala changes and VCI. We also explore how new neuroimaging methods can assess amygdala changes early, laying a foundation for future comprehensive exploration of the pathogenesis of CSVD.
脑小血管病（CSVD）是一种常见的血管疾病，一直与血管性认知障碍（VCI）相关。CSVD的诊断仍依赖于磁共振成像（MRI）。流行病学数据表明，在社区研究中，CSVD的特征性MRI表现，包括白质高信号（WMH）和腔隙性梗死，在40岁以上的人群中非常常见。这种高患病率给许多低收入和中等收入家庭带来了沉重负担。杏仁核在整合感觉和联想信息以调节情绪认知方面起着关键作用。尽管之前许多研究已将杏仁核的改变与各种疾病（如抑郁症）联系起来，但由于CSVD的复杂性，关于CSVD相关的杏仁核改变的研究很少。在本文中，我们总结了CSVD的各种影像学特征，并讨论了杏仁核变化与VCI之间的相关性。我们还探讨了新的神经影像学方法如何早期评估杏仁核变化，为未来全面探索CSVD的发病机制奠定基础。
