Shanghai Ocean University, Shanghai, China.
Central Marine Research and Design Institute, Saint Petersburg, Russia.
BMC Psychiatry. 2023 Sep 22;23(1):691. doi: 10.1186/s12888-023-05172-2.
Prevalence of dementia illness, causing certain morbidity and mortality globally, places burden on global public health. This study primary goal was to assess future risks of dying from severe dementia, given specific return period, within selected group of regions or nations.
Traditional statistical approaches do not have benefits of effectively handling large regional dimensionality, along with nonlinear cross-correlations between various regional observations. In order to produce reliable long-term projections of excessive dementia death rate risks, this study advocates novel bio-system reliability technique, that being particularly suited for multi-regional environmental, biological, and health systems.
Raw clinical data has been used as an input to the suggested population-based, bio-statistical technique using data from medical surveys and several centers.
Novel spatiotemporal health system reliability methodology has been developed and applied to dementia death rates raw clinical data. Suggested methodology shown to be capable of dealing efficiently with spatiotemporal clinical observations of multi-regional nature. Accurate disease risks multi-regional spatiotemporal prediction being done, relevant confidence intervals have been presented as well.
Based on available clinical survey dataset, the proposed approach may be applied in a variety of clinical public health applications. Confidence bands, given for predicted dementia-associated death rate levels with return periods of interest, have been reasonably narrow, indicating practical values of advocated prognostics.
痴呆症在全球范围内导致一定的发病率和死亡率,给全球公共卫生带来负担。本研究的主要目标是评估在选定的地区或国家群体中,给定特定的回报期,从严重痴呆症中死亡的未来风险。
传统的统计方法没有有效处理大区域维度的优势,也不能处理各种区域观测之间的非线性交叉相关性。为了对过高的痴呆死亡率风险进行可靠的长期预测,本研究提倡一种新颖的生物系统可靠性技术,该技术特别适合于多区域环境、生物和卫生系统。
原始临床数据已被用作基于人群的生物统计技术的输入,该技术使用了来自医学调查和多个中心的数据。
开发并应用了新颖的时空卫生系统可靠性方法,对痴呆死亡率的原始临床数据进行了处理。该建议的方法能够有效地处理多区域性质的时空临床观察。对多区域时空疾病风险进行了准确的预测,并给出了相应的置信区间。
基于可用的临床调查数据集,所提出的方法可以应用于各种临床公共卫生应用。对于具有相关回报期的预测痴呆相关死亡率水平,给出了合理狭窄的置信带,表明所提倡的预后具有实际价值。