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补救还是悲剧:与急性肾损伤和感染性心内膜炎相关的诱导性急性氧化溶血:葡萄糖-6-磷酸脱氢酶缺乏症的首例表现:病例报告

Remedy or tragedy: -induced acute oxidative hemolysis associated with acute kidney injury and infective endocarditis: An initial presentation of G6PD Deficiency: A case report.

作者信息

Charles J C, Kiriwandeniya K G K U, Liyanapathirana K V, Gunarathna R D S, Mendis S, Liyanarachchi G G

机构信息

National Hospital of Sri Lanka, Sri Lanka.

出版信息

SAGE Open Med Case Rep. 2024 Jul 26;12:2050313X241266554. doi: 10.1177/2050313X241266554. eCollection 2024.

DOI:10.1177/2050313X241266554
PMID:39071198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11282534/
Abstract

is used as an herbal broth in Sri Lanka for medicinal purposes. It can induce acute oxidative hemolysis and severe methemoglobinemia in G6PD deficiency patients. Leptospirosis is an endemic infection in Sri Lanka, resembling the clinical presentation of acute oxidative hemolysis in G6PD deficiency. As the presentation can mimic leptospirosis, a high index of suspicion is maintained when an infective focus is not identified in patients with fever, jaundice, and hematuria. Here, we present a case of a 33-year-old male patient with hemolysis following herbal broth ingestion. He has recovered from acute oxidative hemolysis with supportive management, but he acquired infective endocarditis during inward stay through the central intravenous line, necessitating valve replacement.

摘要

在斯里兰卡,它被用作药汤用于药用目的。它可在葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症患者中诱发急性氧化性溶血和严重高铁血红蛋白血症。钩端螺旋体病在斯里兰卡是一种地方性感染,类似于G6PD缺乏症中急性氧化性溶血的临床表现。由于其表现可模仿钩端螺旋体病,因此对于发热、黄疸和血尿患者若未发现感染灶,则需高度怀疑。在此,我们报告一例33岁男性患者,在摄入药汤后发生溶血。他通过支持治疗已从急性氧化性溶血康复,但在内科住院期间通过中心静脉导管获得感染性心内膜炎,需要进行瓣膜置换。

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本文引用的文献

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Clinical characteristics and outcomes of patients with leptospirosis complicated with acute pancreatitis: a systematic review.临床特点和结局的患者与 leptospirosis 并发急性胰腺炎:系统评价。
J Int Med Res. 2023 Sep;51(9):3000605231197461. doi: 10.1177/03000605231197461.
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Clinical Characteristics of Poisoning.中毒的临床特征
Int J Gen Med. 2020 Aug 25;13:539-545. doi: 10.2147/IJGM.S263199. eCollection 2020.
3
Case Report: A Case of Acute Intravascular Hemolysis in Dengue Fever.病例报告:登革热致急性血管内溶血 1 例。
Am J Trop Med Hyg. 2020 Feb;102(2):355-358. doi: 10.4269/ajtmh.19-0743.
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A vegetable-induced hemolytic crisis in a G6PD deficient person: a case report.一名葡萄糖-6-磷酸脱氢酶(G6PD)缺乏者的蔬菜诱发溶血性危机:病例报告
BMC Res Notes. 2018 Mar 14;11(1):179. doi: 10.1186/s13104-018-3286-9.
5
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PLoS One. 2017 Feb 2;12(2):e0171208. doi: 10.1371/journal.pone.0171208. eCollection 2017.
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IUBMB Life. 2012 May;64(5):362-9. doi: 10.1002/iub.1017. Epub 2012 Mar 20.
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