Suzuki Jun, Hemmi Tomotaka, Ida Tomoaki, Ogata Seiryo, Yoshitake Jun, Matsunaga Tetsuro, Ishida Tomoyasu, Numano Yuki, Kusano Yusuke, Ikeda Ryoukichi, Nomura Kazuhiro, Sugawara Mitsuru, Ohta Nobuo, Akaike Takaaki, Katori Yukio
Department of Otolaryngology, Head and Neck Surgery Tohoku University Graduate School of Medicine Sendai Japan.
Department of Otolaryngology Tohoku Kosai Hospital Sendai Japan.
Laryngoscope Investig Otolaryngol. 2024 Jul 27;9(4):e1261. doi: 10.1002/lio2.1261. eCollection 2024 Aug.
Disruption of the oxidative stress defense system is involved in developing various diseases. Sulfur compounds such as glutathione (GSH) and cysteine (CysSH) are representative antioxidants in the body. Recently, supersulfides, including reactive persulfide and polysulfide species, have gained attention as potent antioxidants regulating oxidative stress and redox signaling. However, their involvement in the pathogenesis of chronic rhinosinusitis (CRS) remains unclear.
To clarify the changes in sulfur compounds within the sinus mucosa of each CRS subtype, we measured sulfur compound levels in the sinus mucosa of control individuals ( = 9), patients with eosinophilic CRS (ECRS) ( = 13), and those with non-ECRS (nECRS) ( = 11) who underwent sinus surgery using mass spectrometry.
GSH and CysSH levels were significantly reduced, and the glutathione disulfide (GSSG)/GSH ratio, an oxidative stress indicator, was increased in patients with ECRS. Despite the absence of notable variations in supersulfides, patients with ECRS and nECRS exhibited a significant reduction in glutathione trisulfide (GSSSG), which serves as the precursor for supersulfides.
This study is the first quantitative assessment of supersulfides in normal and inflamed sinus mucosa, suggesting that sulfur compounds contribute to the pathogenesis of CRS.
N/A.
氧化应激防御系统的破坏与多种疾病的发生发展有关。谷胱甘肽（GSH）和半胱氨酸（CysSH）等含硫化合物是体内具有代表性的抗氧化剂。近来，包括反应性过硫化物和多硫化物在内的超硫化物作为调节氧化应激和氧化还原信号的强效抗氧化剂受到关注。然而，它们在慢性鼻窦炎（CRS）发病机制中的作用仍不明确。
为明确各CRS亚型鼻窦黏膜中含硫化合物的变化情况，我们采用质谱法测定了接受鼻窦手术的对照个体（n = 9）、嗜酸性粒细胞性CRS（ECRS）患者（n = 13）和非嗜酸性粒细胞性CRS（nECRS）患者（n = 11）鼻窦黏膜中的含硫化合物水平。
ECRS患者的GSH和CysSH水平显著降低，氧化应激指标谷胱甘肽二硫化物（GSSG）/GSH比值升高。尽管超硫化物无明显变化，但ECRS和nECRS患者的谷胱甘肽三硫化物（GSSSG）显著降低，而GSSSG是超硫化物的前体。
本研究首次对正常和炎症鼻窦黏膜中的超硫化物进行了定量评估，提示含硫化合物在CRS发病机制中起作用。
无。
