Qiao Xiuqi, Wang Xiaoxia, Guo Lixin, Pan Qi
Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.
Nat Sci Sleep. 2024 Jul 24;16:1067-1074. doi: 10.2147/NSS.S468444. eCollection 2024.
Prior research based on observations has furnished evidence that supports a connection between daytime napping and the prevalence of non-alcoholic fatty liver disease (NAFLD). Nevertheless, the question of whether this correlation is indicative of a causal link has not been definitively answered.
We used meta-analysis and Mendelian randomization (MR) to synthesize genetic and observational data. A two-sample MR analysis was conducted, leveraging 105 single-nucleotide polymorphisms (SNPs) known to be associated with daytime napping patterns. Additionally, summary-level data pertaining to NAFLD outcomes were acquired from the comprehensive UK Biobank study. Network meta-analyses were employed to investigate the relationship between excessive daytime napping and NAFLD, while subgroup was also performed.
Significant associations were observed between daytime napping and NAFLD. The systematic review/meta-analysis uncovered a heightened risk of NAFLD development among individuals who engaged in daytime naps exceeding 30 minutes, when compared to those who did not nap(odds ratio [OR] = 1.32, 95% confidence interval [CI]: 1.05 to 1.66). Furthermore, MR analysis indicated that a genetic propensity towards longer daytime napping was significantly linked to an increased likelihood of NAFLD (OR = 2.26, 95% CI: 1.38 to 3.73).
Daytime napping has been found to be causally related to a higher risk of NAFLD. Furthermore, across all participants, napping for an average duration over 30 minutes was linked to an elevated likelihood of NAFLD.
先前基于观察的研究提供了证据，支持白天小睡与非酒精性脂肪性肝病（NAFLD）患病率之间存在关联。然而，这种相关性是否表明存在因果关系的问题尚未得到明确解答。
我们使用荟萃分析和孟德尔随机化（MR）来综合遗传和观察数据。进行了两样本MR分析，利用了105个已知与白天小睡模式相关的单核苷酸多态性（SNP）。此外，从全面的英国生物银行研究中获取了与NAFLD结果相关的汇总数据。采用网络荟萃分析来研究白天过度小睡与NAFLD之间的关系，并进行了亚组分析。
观察到白天小睡与NAFLD之间存在显著关联。系统评价/荟萃分析发现，与不午睡的人相比，午睡超过30分钟的人患NAFLD的风险更高（优势比[OR]=1.32，95%置信区间[CI]：1.05至1.66）。此外，MR分析表明，白天小睡时间较长的遗传倾向与NAFLD风险增加显著相关（OR=2.26，95%CI：1.38至3.73）。
已发现白天小睡与NAFLD风险较高存在因果关系。此外，在所有参与者中，平均午睡时间超过30分钟与NAFLD可能性增加有关。
