Panda Chinmayee, Rathinasabapathy Thirumurugan, Metzger Brandon, Dodson Sheila, Hanson Dirk, Griffiths Jody, Komarnytsky Slavko
Nutrition Innovation Center, Standard Process, Kannapolis, NC, United States.
Plants for Human Health Institute, NC State University, Kannapolis, NC, United States.
Front Vet Sci. 2024 Jul 12;11:1384168. doi: 10.3389/fvets.2024.1384168. eCollection 2024.
Lameness and restricted mobility are a significant concern in companion animals experiencing chronic pain, inflammation, or age-related pathologies. The growing awareness of health risks and side effects associated with the long-term use of prescription analgesics requires different management strategies to address these issues. In this study, we conducted a crossover evaluation of the effect of full spectrum hemp oil dosed orally at 2 mg/kg BID phytocannabinoids for 8 weeks in dogs ( = 37) living with pain in common household settings. Owner-reported canine pain, home activity, accelerometer-based activity, walkway-based gait, and tolerability were assessed at each phase of the study. Secondary endpoints included changes in blood biochemistry, liver enzymes, inflammatory biomarkers, and plasma metabolites. The intervention was positively associated with a decrease in pain scores (-46.2%, = 0.0016), increased ability to walk up and down the stairs (10.6-14.7%, < 0.05), and improved daily activity (25.9%, = 0.0038). Decreases in plasma levels of proinflammatory cytokines TNF-α, IL-6, and IL-8 were also observed. Taken together, these findings suggest that the benefits of nutritional supplementation with hemp oil could include control of pain, greater mobility, and an overall improvement in the animal wellbeing.
跛行和行动受限是患有慢性疼痛、炎症或与年龄相关疾病的伴侣动物的一个重大问题。人们越来越意识到长期使用处方镇痛药带来的健康风险和副作用，这就需要不同的管理策略来解决这些问题。在本研究中，我们对37只生活在普通家庭环境中且患有疼痛的犬进行了一项交叉评估，评估口服2mg/kg bid植物大麻素的全谱大麻油8周的效果。在研究的每个阶段，评估了主人报告的犬类疼痛、家庭活动、基于加速度计的活动、基于人行道的步态和耐受性。次要终点包括血液生化、肝酶、炎症生物标志物和血浆代谢物的变化。干预措施与疼痛评分降低（-46.2%，P = 0.0016）、上下楼梯能力提高（10.6 - 14.7%，P < 0.05）以及日常活动改善（25.9%，P = 0.0038）呈正相关。还观察到促炎细胞因子TNF-α、IL-6和IL-8的血浆水平降低。综上所述，这些发现表明，用大麻油进行营养补充的益处可能包括控制疼痛、提高活动能力以及总体改善动物健康状况。
