Tan Xiang, Wang Botao, Zhou Xu, Liu Cuiping, Wang Chen, Bai Junying
Citrus Research Institute, Southwest University, Chongqing, 400700, China.
Bloomage Biotechnology CO, LTD, Jinan, Shandong, 250000, China.
Food Chem X. 2024 Jul 2;23:101610. doi: 10.1016/j.fochx.2024.101610. eCollection 2024 Oct 30.
Dietary fiber targets the regulation of the intestinal flora and thus affects host health, however, the complex relationship between these factors lacks direct evidence. In this study, the regulatory effects of Konjac glucomannan (KGM) on key metabolites of host intestinal flora were examined by using fermentation. The results showed that KGM could be utilized by the intestinal flora, which inhibited the relative abundance of , , , and and enriched the relative abundance of , Fermentation is accompanied by the production of short-chain acids, including acetic and propionic acids. Metabolomics revealed that KGM significantly promoted amino acid metabolism, lipid metabolism, and the biosynthesis of other secondary metabolites. Correlation analysis results showed that the increase of panose and N-(1-carboxy-3-carboxanilidopropyl) alanylproline content was positively correlated with the relative abundance of . These results provide evidence that KGM affects host health by regulating gut microbiota and its metabolites.
膳食纤维靶向调节肠道菌群，从而影响宿主健康，然而，这些因素之间的复杂关系缺乏直接证据。在本研究中，通过发酵研究了魔芋葡甘聚糖（KGM）对宿主肠道菌群关键代谢产物的调节作用。结果表明，肠道菌群可利用KGM，其抑制了[未提及具体菌群名称]、[未提及具体菌群名称]、[未提及具体菌群名称]和[未提及具体菌群名称]的相对丰度，并富集了[未提及具体菌群名称]、[未提及具体菌群名称]的相对丰度。发酵伴随着短链酸的产生，包括乙酸和丙酸。代谢组学显示，KGM显著促进了氨基酸代谢、脂质代谢以及其他次生代谢产物的生物合成。相关性分析结果表明，潘糖和N-（1-羧基-3-羧基苯胺基丙基）丙氨酰脯氨酸含量的增加与[未提及具体菌群名称]的相对丰度呈正相关。这些结果提供了证据，表明KGM通过调节肠道微生物群及其代谢产物来影响宿主健康。
