Bai Junying, Wang Botao, Tan Xiang, Huang Linhua, Xiong Shuangli
Citrus Research Institute, Southwest University, Chongqing 400700, China.
National Citrus Engineering Research Center, Chongqing 400700, China.
Food Chem X. 2023 Aug 11;19:100821. doi: 10.1016/j.fochx.2023.100821. eCollection 2023 Oct 30.
Lactulose is a common component in foods. However, the effect of lactulose on intestinal flora and overall metabolic levels remains unclear. Therefore, this study aims to explore the regulative role of lactulose on intestinal flora and serum metabolites via simulated colonic fermentation model and colitis mouse model. The results showed that lactulose significantly enriched beneficial bacteria including and , and reduced pathogenic bacteria such as . Moreover, lactulose significantly inhibited dextran sodium sulfate-induced body weight loss, colon shortening, colonic inflammatory infiltration, and pro-inflammatory cytokines IL-6, TNF-α, IL-17, and IL-1β. Lactulose significantly affected serum metabolome in colitis mice and total 24 metabolites representing a high inter-group difference were obtained. Correlation analysis revealed that the changes in serum metabolites were closely associated with the role of intestinal flora, and thus affected phenotypic indicators. Our study provides a reference for nutritional characteristics and application scenarios of dietary lactulose.
乳果糖是食品中的常见成分。然而，乳果糖对肠道菌群和整体代谢水平的影响仍不清楚。因此，本研究旨在通过模拟结肠发酵模型和结肠炎小鼠模型探讨乳果糖对肠道菌群和血清代谢物的调节作用。结果表明，乳果糖显著富集了包括[具体有益菌名称1]和[具体有益菌名称2]在内的有益菌，并减少了诸如[具体病原菌名称]等病原菌。此外，乳果糖显著抑制了葡聚糖硫酸钠诱导的体重减轻、结肠缩短、结肠炎症浸润以及促炎细胞因子IL-6、TNF-α、IL-17和IL-1β。乳果糖显著影响结肠炎小鼠的血清代谢组，共获得24种组间差异较大的代谢物。相关性分析表明，血清代谢物的变化与肠道菌群的作用密切相关，进而影响表型指标。本研究为膳食乳果糖的营养特性和应用场景提供了参考。
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