Biddle Jessica E, Nguyen Huong Q, Talbot H Keipp, Rolfes Melissa A, Biggerstaff Matthew, Johnson Sheroi, Reed Carrie, Belongia Edward A, Grijalva Carlos G, Mellis Alexandra M
Centers for Disease Control and Prevention, Atlanta, Georgia.
Marshfield Clinic Research Institute, Marshfield, Wisconsin.
medRxiv. 2024 Jul 18:2024.07.17.24310569. doi: 10.1101/2024.07.17.24310569.
Asymptomatic influenza virus infection occurs but may vary by factors such as age, influenza vaccination status, or influenza season. We examined the frequency of influenza virus infection and associated symptoms using data from two case-ascertained household transmission studies (conducted from 2017-2023) with prospective, systematic collection of respiratory specimens and symptoms. From the 426 influenza virus infected household contacts that met our inclusion criteria, 8% were asymptomatic, 6% had non-respiratory symptoms, 23% had acute respiratory symptoms, and 62% had influenza-like illness symptoms. Understanding the prevalence of asymptomatic and mildly symptomatic influenza cases is important for implementing effective influenza prevention strategies and enhancing the effectiveness of symptom-based surveillance systems.
无症状流感病毒感染确实会发生，但可能因年龄、流感疫苗接种状况或流感季节等因素而有所不同。我们利用两项病例确诊的家庭传播研究（于2017年至2023年开展）的数据，前瞻性、系统性地收集呼吸道标本和症状，研究了流感病毒感染的频率及相关症状。在符合我们纳入标准的426名感染流感病毒的家庭接触者中，8%无症状，6%有非呼吸道症状，23%有急性呼吸道症状，62%有流感样疾病症状。了解无症状和轻度症状流感病例的流行情况对于实施有效的流感预防策略以及提高基于症状的监测系统的有效性至关重要。
