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小分子作为……荧光探针的概述

Overview of Small Molecules as Fluorescent Probes of .

作者信息

Stavropoulou Konstantina, Papanastasiou Ioannis P

机构信息

Division of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece.

出版信息

ACS Omega. 2024 Jul 9;9(29):31220-31227. doi: 10.1021/acsomega.4c01992. eCollection 2024 Jul 23.

DOI:10.1021/acsomega.4c01992
PMID:39072060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11270572/
Abstract

Tuberculosis (TB) remains one of the leading infectious causes of death worldwide. Detecting and precisely quantifying viable () is crucial for comprehending mycobacterial pathogenicity; the progression and outcomes of tuberculosis; and the action, efficacy, and resistance of drugs. Fluorescent probes have emerged as indispensable tools for studying the intricate structure and dynamic interactions of with its host environment. This minireview underscores the significance of small molecules as fluorescent probes in advancing our understanding of mycobacterial biology and highlights their potential for guiding the development of novel therapeutic interventions against tuberculosis.

摘要

结核病（TB）仍然是全球主要的感染性死亡原因之一。检测并精确量化活的（此处原文括号内容缺失）对于理解分枝杆菌致病性、结核病的进展和转归以及药物的作用、疗效和耐药性至关重要。荧光探针已成为研究（此处原文括号内容缺失）与其宿主环境的复杂结构和动态相互作用的不可或缺的工具。这篇小型综述强调了小分子作为荧光探针在增进我们对分枝杆菌生物学的理解方面的重要性，并突出了它们在指导开发新型抗结核治疗干预措施方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/bcffc604dcfe/ao4c01992_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/cf544027cc0f/ao4c01992_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/9dbe4f620975/ao4c01992_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/16f7f58fb734/ao4c01992_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/b73268c79818/ao4c01992_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/c64cb971d265/ao4c01992_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/f4a37927d193/ao4c01992_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/fceae0630b67/ao4c01992_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/fb79909d078f/ao4c01992_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/bcffc604dcfe/ao4c01992_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/cf544027cc0f/ao4c01992_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/9dbe4f620975/ao4c01992_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/16f7f58fb734/ao4c01992_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/b73268c79818/ao4c01992_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/c64cb971d265/ao4c01992_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/f4a37927d193/ao4c01992_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/fceae0630b67/ao4c01992_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/fb79909d078f/ao4c01992_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/225a/11270572/bcffc604dcfe/ao4c01992_0009.jpg

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