Renan Oliveira Leila, Sá Magalhães Serafim Mateus, Lanza Dias Diego, Freitas Túlio Resende, Abrahao Jonatas Santos, de Medeiros Antar Guilherme, Mota Bruno E F, Sabino Adriano de Paula, Pains Duarte Lucienir, Vidal Diogo Montes, Faria de Sousa Grasiely
Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte ,MG 31270-901, Brazil.
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte ,MG 31270-901, Brazil.
ACS Omega. 2024 Jul 11;9(29):32153-32158. doi: 10.1021/acsomega.4c04360. eCollection 2024 Jul 23.
is naturally found in the Atlantic Forest regions of Brazil. Despite the pharmacological potential of plants from the genus, phytochemical studies on this species have not been reported in literature. A new triterpene, 28-hydroxyfriedelane-3,15-dione (), and seven known compounds (friedelan-3-one (), friedelan-3β-ol (), friedelane-3,15-dione (), 15α-hydroxyfriedelan-3-one (), 28-hydroxyfriedelan-3-one (), 30-hydroxyfriedelan-3-one (), and 29-hydroxyfriedelan-3-one ()) were obtained from the hexane extract of leaves. These isolated compounds and three extracts, hexane (), chloroform (), and ethyl acetate (), were assessed for their potential biological activities, which consisted in the evaluation of antiviral activity against a murine coronavirus, mouse hepatitis virus 3 (MHV-3), antibacterial activity against the susceptible and methicillin-resistant (MRSA), and antileukemia activity against the THP-1 and K-562 cell lines. The extracts and along with the triterpenes and exhibited moderate to high antiviral activity, with emphasis on , which presented an EC value of 2.9 ± 0.3 μM. None of the compounds presented antibacterial activity against the tested strains. The evaluated compounds , , and exhibited low cytotoxic activity against the tested leukemia cell lines. Taken together, this study comprises an overview for the potential of the biological activities, including a new isolated triterpene.
天然存在于巴西的大西洋森林地区。尽管该属植物具有药理潜力，但尚未见文献报道对该物种进行的植物化学研究。从叶的己烷提取物中获得了一种新的三萜，28 - 羟基木栓烷 - 3,15 - 二酮（），以及七种已知化合物（木栓烷 - 3 - 酮（）、木栓烷 - 3β - 醇（）、木栓烷 - 3,15 - 二酮（）、15α - 羟基木栓烷 - 3 - 酮（）、28 - 羟基木栓烷 - 3 - 酮（）、30 - 羟基木栓烷 - 3 - 酮（）和29 - 羟基木栓烷 - 3 - 酮（））。对这些分离得到的化合物以及三种提取物，即己烷（）、氯仿（）和乙酸乙酯（），进行了潜在生物活性评估，包括评估对鼠冠状病毒、小鼠肝炎病毒3型（MHV - 3）的抗病毒活性，对敏感和耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性，以及对THP - 1和K - 562细胞系的抗白血病活性。提取物和以及三萜和表现出中度至高抗病毒活性，其中尤为突出，其EC值为2.9±0.3μM。所有化合物对测试菌株均无抗菌活性。所评估的化合物、、和对测试的白血病细胞系表现出低细胞毒性活性。综上所述，本研究概述了该生物活性的潜力，包括一种新分离的三萜。
